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[基于核酸代谢指标的氧化氚的相对生物学效应]

[Relative biological effectiveness of tritium oxide based on nucleic acid metabolic indices].

作者信息

Shorokhova V B, Mushkacheva G S

出版信息

Radiobiologiia. 1985 Sep-Oct;25(5):622-5.

PMID:4070568
Abstract

Relative biological effectiveness (RBE) of tritium oxide, as compared to gamma-rays (137Cs), with regard to LD50/30 is 2,32 +/- 0,69 for rats. The RBE coefficients for tritium oxide are obtained with regard to some indices of nucleic acid metabolism in the thymus and spleen during the dose formation (0-14 days). The RBE of tritium oxide increases with a decrease in radiation dose as determined according to the concentration and content of DNA per organ and activity of thymus DNAases.

摘要

与γ射线(137Cs)相比,氧化氚对大鼠LD50/30的相对生物效能(RBE)为2.32±0.69。氧化氚的RBE系数是根据剂量形成期(0 - 14天)胸腺和脾脏中核酸代谢的一些指标得出的。根据每个器官的DNA浓度和含量以及胸腺DNA酶的活性确定,氧化氚的RBE随辐射剂量的降低而增加。

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