Mushkacheva G S, Shorokhova V B
Radiobiologiia. 1989 Jul-Aug;29(4):554-7.
A single injection of tritium oxide in a dose of 1.1 MBq/g (0.5 Gy for 30 days) was shown to impair the nucleic acid metabolism in the rat spleen. The changes in the indices under study (e.g. mass, nucleic acid content and biosynthesis) increased with the dose, and the recovery started later and was incomplete. Qualitative differences were found in the effects of tritium oxide and gamma radiation with regard to the rate of DNA biosynthesis: 24 h following the injection of the radionuclide specific activity of DNA increased with dose, whereas this function was inverse in the case of gamma irradiation as it was reported in the literature.
已表明，以1.1 MBq/g的剂量单次注射氧化氚（30天内为0.5 Gy）会损害大鼠脾脏中的核酸代谢。所研究指标（如质量、核酸含量和生物合成）的变化随剂量增加，恢复开始较晚且不完全。在DNA生物合成速率方面，发现氧化氚和γ辐射的影响存在质的差异：注射放射性核素后24小时，DNA的比活性随剂量增加，而如文献报道，γ辐射情况下此功能则相反。
