Liu Na, Zhang Huichen, Lixia Gao, Fang Xiaoqing, Li Qing, Li Min, Wang Lin, Ma Kun, Ding Xuemei, Zhang Xiaoli
Binzhou Medical University, Yantai, Shandong, China.
Dezhou Vocational and Technical College, Dezhou, Shandong, China.
BMJ Open. 2025 Jul 24;15(7):e099195. doi: 10.1136/bmjopen-2025-099195.
To investigate whether positive cognitive emotion regulation (PCER) and sense of coherence (SOC) mediate the relationship between family hardiness (FH) and post-traumatic growth (PTG) in patients with lung cancer undergoing chemotherapy.
Cross-sectional study, convenience sampling method and mediation analyses.
All participants were from two hospitals in Shandong, China.
321 patients with lung cancer who underwent chemotherapy between April and September 2022 at two hospitals in Shandong province, China.
The Family Hardiness Index, Cognitive Emotion Regulation Questionnaire, Sense of Coherence Scale and Post-Traumatic Growth Inventory.
PTG was positively associated with FH (r=0.33, p<0.01), PCER (r=0.31, p<0.01) and SOC (r=0.37, p<0.01). FH was positively associated with PCER (r=0.31, p<0.01) and SOC (r=0.40, p<0.01). PCER was positively associated with SOC (r=0.32, p<0.01). The mediation analysis showed that FH affected PTG (β=0.235, p<0.05) directly and indirectly through PCER and SOC (β=0.097, 0.142, p<0.05). The mediating effects of PCER and SOC accounted for 20.46% and 29.96%, respectively, of the total effect (FH → PTG).
PCER and SOC mediated the relationship between FH and PTG in patients with lung cancer undergoing chemotherapy. Thus, future interventional studies should consider PCER and SOC as targets for developing PTG in patients with lung cancer receiving chemotherapy.
探讨积极认知情绪调节（PCER）和连贯感（SOC）是否介导了接受化疗的肺癌患者的家庭坚韧性（FH）与创伤后成长（PTG）之间的关系。
横断面研究、便利抽样法及中介分析。
所有参与者均来自中国山东的两家医院。
2022年4月至9月在中国山东省两家医院接受化疗的321例肺癌患者。
家庭坚韧性指数、认知情绪调节问卷、连贯感量表和创伤后成长量表。
PTG与FH（r = 0.33，p < 0.01）、PCER（r = 0.31，p < 0.01）和SOC（r = 0.37，p < 0.01）呈正相关。FH与PCER（r = 0.31，p < 0.01）和SOC（r = 0.40，p < 0.01）呈正相关。PCER与SOC呈正相关（r = 0.32，p < 0.01）。中介分析表明，FH直接（β = 0.235，p < 0.05）和间接通过PCER和SOC（β = 0.097，0.142，p < 0.05）影响PTG。PCER和SOC的中介效应分别占总效应（FH→PTG）的20.46%和29.96%。
PCER和SOC介导了接受化疗的肺癌患者FH与PTG之间的关系。因此，未来的干预研究应将PCER和SOC作为促进接受化疗的肺癌患者PTG的靶点。
