Effect of the hypothyroidism on the levels of different metabolites in pregnant rats.

The effect of gestational hypothyroidism on some maternal and foetal metabolites were studied on pregnant rats after 24 h fasting. Thyroidectomy induced a decrease in body weight in the pregnant rats. Their foetuses showed lower weights than the controls. No difference was found in circulating glucose levels in the thyroidectomized pregnant rats, although an increase was found in their foetuses. Hepatic glycogen and total serum lipids decrease in hypothyroid pregnant rats. Cholesterol concentration increases as a result of hypothyroidism. However, foetuses coming from thyroidectomized mothers show an increase in their total lipid levels. Hypothyroidism in pregnant rats affects foetal development and metabolic changes are greatly manifested in the starved condition.