慢性阻塞性肺疾病患者运动时的右心室功能。氧气的影响。

Right ventricular performance during exercise in chronic obstructive pulmonary disease. The effects of oxygen.

作者信息

MacNee W, Morgan A D, Wathen C G, Muir A L, Flenley D C

出版信息

Respiration. 1985;48(3):206-15. doi: 10.1159/000194831.

DOI:10.1159/000194831

Abstract

Radionuclide ventriculography allows non-invasive assessment of right ventricular performance. This study has confirmed that there is a modest reduction in right ventricular ejection fraction (RVEF) in patients with chronic obstructive pulmonary disease (COPD), as compared to normal subjects. However, occult right ventricular dysfunction also becomes apparent in these patients during exercise. The change in RVEF during exercise is related to the corresponding fall in arterial oxygen saturation in patients with COPD. Oxygen improves the response of the right ventricle to exercise, although the mechanism remains unclear. Long-term oxygen therapy, in patients with respiratory failure, does not appear to have any significant effect on RVEF.

摘要

放射性核素心室造影术可对右心室功能进行无创评估。本研究证实，与正常受试者相比，慢性阻塞性肺疾病（COPD）患者的右心室射血分数（RVEF）有适度降低。然而，这些患者在运动时隐匿性右心室功能障碍也会变得明显。COPD患者运动期间RVEF的变化与动脉血氧饱和度的相应下降有关。尽管机制尚不清楚，但吸氧可改善右心室对运动的反应。对于呼吸衰竭患者，长期氧疗似乎对RVEF没有任何显著影响。