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150例后入路机器人辅助根治性前列腺切除术早期疗效的比较分析及学习曲线的确定:单术者系列研究

Comparative analysis of early outcomes of the first 150 cases of posterior approach robotic-assisted radical prostatectomy and identification of the learning curve: A single-surgeon series.

作者信息

Tay Li June, Pan Henry Y C, Spurling Leigh James, Dundee Philip

机构信息

Department of Urology East Kent Hospital NHS Trust Canterbury UK.

Department of Urology The Royal Melbourne Hospital Parkville Victoria Australia.

出版信息

BJUI Compass. 2025 Jul 23;6(7):e70058. doi: 10.1002/bco2.70058. eCollection 2025 Jul.

Abstract

OBJECTIVES

To report intraoperative and early postoperative outcomes of posterior approach Robotic Assisted Radical Prostatectomy (RARP) patients and analyse a single-surgeon learning curve.

PATIENTS & METHODS: The initial 150 patients undergoing posterior approach RARP by a single surgeon were analysed in three equal cohorts. Initial postoperative follow-up was for a minimum of 3 months.

RESULTS

A total of 150 patients were included. These cases were performed between April 2017 to June 2024. There was no significant difference in pre-operative patient age, prostate specific antigen (PSA), body mass index (BMI), prostate volume, number of biopsy positive cores, International Society of Urological Pathologists (ISUP) grade group and clinical T-stage.Intraoperative differences between cohorts were decreasing total operative time (153 min vs 121 min vs 106 min, p < 0.001) and estimated blood loss (296 ml vs 205 ml vs 199 ml, p < 0.001), but no difference in nerve sparing status (p = 0.243).Postoperatively, no difference was found in median length of stay, ISUP grade group, tumour volume, 30-day readmissions or complications. There were significant differences in overall pathological T stage (p = 0.004) between the cohorts, but not positive margin status, even with T2/T3 disease. There was a significant difference in early continence recovery within the first week (p = 0.022) and at 1 month (0.041) but no difference between overall continence recovery and erectile function recovery.

CONCLUSIONS

Estimated blood loss and total operative time decreased across the cohorts, despite worsening disease burden. Oncological and functional outcomes are excellent throughout when compared with published literature. The learning curve may be facilitated initially by careful patient selection. Posterior approach RARP could be safely adopted by urologists adept in standard RARP, and structured training may improve the uptake of this technique.

摘要

目的

报告后入路机器人辅助根治性前列腺切除术(RARP)患者的术中及术后早期结果,并分析单术者的学习曲线。

患者与方法

对由单术者进行后入路RARP的最初150例患者按三个相等队列进行分析。术后初始随访至少3个月。

结果

共纳入150例患者。这些病例于2017年4月至2024年6月期间进行。术前患者年龄、前列腺特异性抗原(PSA)、体重指数(BMI)、前列腺体积、活检阳性芯数量、国际泌尿病理学家协会(ISUP)分级组和临床T分期无显著差异。队列间术中差异在于总手术时间减少(153分钟对121分钟对106分钟,p<0.001)和估计失血量(296毫升对205毫升对199毫升,p<0.001),但在保留神经状态方面无差异(p = 0.243)。术后,中位住院时间、ISUP分级组、肿瘤体积、30天再入院率或并发症方面无差异。队列间总体病理T分期有显著差异(p = 0.004),但切缘阳性状态无差异,即使是T2/T3期疾病。术后第一周(p = 0.022)和1个月时(p = 0.041)早期控尿恢复有显著差异,但总体控尿恢复和勃起功能恢复之间无差异。

结论

尽管疾病负担加重,但各队列的估计失血量和总手术时间均减少。与已发表文献相比,整个过程中的肿瘤学和功能结果均良好。最初可通过仔细的患者选择来促进学习曲线。擅长标准RARP的泌尿外科医生可安全采用后入路RARP,结构化培训可能会提高该技术的应用率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c8/12286756/6883e1867d8a/BCO2-6-e70058-g001.jpg

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