Pang Xue, Xu Fengxia, Fan Chang, Jiang Hui
Clinical Research Experiment Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China.
College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230011, Anhui, China.
Clin Rheumatol. 2025 Jan;44(1):53-66. doi: 10.1007/s10067-024-07250-6. Epub 2024 Nov 28.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder, and a growing body of research has demonstrated the involvement and regulatory roles of microRNAs (miRNAs) in the pathogenesis of RA. Consequently, this study aims to evaluate the current status and emerging trends in miRNA research related to RA by employing bibliometric analyses from a comprehensive perspective.
Relevant literature pertaining to miRNA-related RA was systematically searched and screened from the Web of Science Core Collection (WOSCC) database, covering the period from January 1, 2010 to June 30, 2024. Subsequently, the data were subjected to visual analysis using CiteSpace, VOSviewer, the R package, and Bibliometric. This comprehensive approach aimed to elucidate the global state of research, as well as to identify prevailing trends and emerging hotspots within the field.
A comprehensive analysis included 843 publications authored by 4451 researchers from 1096 institutions across 47 countries/regions, with relevant articles disseminated through 297 journals. China emerged as the leading contributor in terms of research output. Specifically, China Medical University and the researcher Chih-Hsin Tang were identified as the most influential institution and author, respectively. "Frontiers in Immunology" was recognized as the most prolific journal, whereas "Arthritis Research & Therapy" garnered the highest number of citations. Notably, Stanczyk's 2008 study published in "Arthritis & Rheumatism" received the highest citation count. Additionally, related research areas such as circular RNAs (circRNAs) and extracellular vesicles (EVs) have become new hotspots in the field.
MiRNAs have garnered significant interest among researchers studying RA, as they show considerable potential for improving RA diagnosis and treatment. As research in this area advances, it is anticipated that scholars will allocate more resources to investigating circRNAs and EVs associated with miRNAs. This focus is expected to provide valuable insights for identifying novel therapeutic targets and drug delivery vectors for RA.
类风湿性关节炎（RA）是一种慢性自身免疫性疾病，越来越多的研究表明微小RNA（miRNA）参与RA的发病机制并发挥调节作用。因此，本研究旨在通过全面的文献计量分析来评估与RA相关的miRNA研究的现状和新趋势。
从Web of Science核心合集（WOSCC）数据库中系统检索和筛选与miRNA相关的RA的相关文献，涵盖2010年1月1日至2024年6月30日期间。随后，使用CiteSpace、VOSviewer、R包和文献计量学对数据进行可视化分析。这种综合方法旨在阐明全球研究状况，并识别该领域的主要趋势和新热点。
综合分析包括来自47个国家/地区1096个机构的4451名研究人员撰写的843篇出版物，相关文章发表在297种期刊上。中国在研究产出方面成为主要贡献者。具体而言，中国医科大学和研究者唐志新分别被确定为最具影响力的机构和作者。《免疫学前沿》被认为是发文量最多的期刊，而《关节炎研究与治疗》获得的引用次数最多。值得注意的是，斯坦奇克2008年发表在《关节炎与风湿病》上的研究获得了最高引用次数。此外，环状RNA（circRNA）和细胞外囊泡（EV）等相关研究领域已成为该领域的新热点。
miRNA在研究RA的研究人员中引起了极大兴趣，因为它们在改善RA诊断和治疗方面显示出相当大的潜力。随着该领域研究的推进，预计学者们将分配更多资源来研究与miRNA相关的circRNA和EV。这一重点有望为确定RA的新型治疗靶点和药物递送载体提供有价值的见解。
