Saffar Soflaei Sara, Salehi-Sangani Pooria, Fallahi Zahra, Imanparast Fatemeh, Marousi Mahdieh, Tajfard Mohammad, Ferns Gordon A, Moohebati Mohsen, Ghayour-Mobarhan Majid
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Endocrinol Diabetes Metab. 2025 Mar;8(2):e70025. doi: 10.1002/edm2.70025.
Despite previous studies, the relationship between the triglyceride-glucose (TyG) index and coronary artery disease (CAD) is still undetermined. So we aimed to investigate the association between the TyG index and CAD.
A total of 2346 subjects were enrolled in the study and were categorised into 5: those with no CAD, angiogram negative (Ang-) patients, those with single-vessel disease (SVD), or two-vessel disease (2VD) or three-vessel disease (3VD). Demographic characteristics, disease history and biochemical investigations were recorded. TyG index was calculated as Ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2].
Adjusted regression models demonstrated that the odds of 3VD (OR, 5.847; 95% CI, 4.391-7.784), 2VD (OR, 4.943; 95% CI, 3.597-6.791), SVD (OR, 4.722; 95% CI 3.448-6.647) and a negative coronary angiogram (OR, 3.137; 95% CI, 2.431-4.049), increased significantly per each unit elevation of the TyG index, compared to the healthy participants. Also, the odds for being 3VD (1.864, 95%CI 1.402-2.477, p-value < 0.001), 2VD (1.575, 95%CI 1.143-2.171, p-value = 0.005) and SVD (1.505, 95%CI 1.097-2.065, p-value = 0.011) were increased significantly by one-unit elevation of TyG index, compared to Ang- group.
Our study demonstrates a significant association between elevated TyG index and the presence and severity of CAD. Higher TyG index values were consistently linked to an increased likelihood of multivessel CAD, especially in diabetic patients. These findings suggest that the TyG index could serve as a valuable marker for assessing CAD risk and stratification.
尽管先前已有研究，但甘油三酯-葡萄糖（TyG）指数与冠状动脉疾病（CAD）之间的关系仍不明确。因此，我们旨在研究TyG指数与CAD之间的关联。
共有2346名受试者参与本研究，并被分为5组：无CAD者、血管造影阴性（Ang-）患者、单支血管病变（SVD）患者、双支血管病变（2VD）患者或三支血管病变（3VD）患者。记录人口统计学特征、疾病史和生化检查结果。TyG指数的计算方法为：Ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。
校正回归模型显示，与健康参与者相比，TyG指数每升高一个单位，3VD（比值比[OR]，5.847；95%置信区间[CI]，4.391 - 7.784）、2VD（OR，4.943；95%CI，3.597 - 6.791）、SVD（OR，4.722；95%CI 3.448 - 6.647）以及冠状动脉造影阴性（OR，3.137；95%CI，2.431 - 4.049）的发生几率均显著增加。此外，与Ang-组相比，TyG指数每升高一个单位，3VD（1.864，95%CI 1.402 - 2.477，p值<0.001）、2VD（1.575，95%CI 1.143 - 2.171，p值 = 0.005）和SVD（1.505，95%CI 1.097 - 2.065，p值 = 0.011）的发生几率也显著增加。
我们的研究表明，TyG指数升高与CAD的存在及严重程度之间存在显著关联。较高的TyG指数值一直与多支血管CAD的发生可能性增加相关，尤其是在糖尿病患者中。这些发现表明，TyG指数可作为评估CAD风险和分层的有价值标志物。
