Kim S N, Fitzgerald J E, De La Iglesia F A
Toxicol Pathol. 1985;13(3):215-21. doi: 10.1177/019262338501300308.
During the necropsy of a 2-yr-old untreated control rat from a carcinogenicity study, a tan brown nodular mass was observed within the tunica albuginea of one testis. Both testes were processed for light and transmission electron microscopy. Histologically, the testicular mass was composed of round to polyhedral cells with distinct cell boundaries, amphophilic cytoplasm, fine nuclear chromatin, and a delicate fibrovascular supporting stroma. Ultrastructurally, the tumor cells displayed features associated with spermatocytic differentiation. Based on the light microscopic and the ultrastructural features, the tumor was considered a spermatocytic seminoma of the testis, a rare tumor in the rat.
在一项致癌性研究中，对一只2岁未经处理的对照大鼠进行尸检时，在一侧睾丸的白膜内观察到一个棕褐色结节状肿块。对双侧睾丸进行了光镜和透射电镜检查。组织学上，睾丸肿块由圆形至多面形细胞组成，细胞边界清晰，胞质嗜两性，核染色质细腻，有纤细的纤维血管支持性间质。超微结构上，肿瘤细胞表现出与精母细胞分化相关的特征。基于光镜和超微结构特征，该肿瘤被认为是睾丸精母细胞性 seminoma，这在大鼠中是一种罕见的肿瘤。 （注：seminoma一般译为精原细胞瘤，这里原文未完整给出准确中文术语，推测是精母细胞性精原细胞瘤 ）
