Mitsumori K, Elwell M R
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Environ Health Perspect. 1988 Apr;77:11-21. doi: 10.1289/ehp.887711.
The incidences of all primary neoplasms in the testes and accessory reproductive organs of 51,230 male Fischer 344 (F344) rats and 46,752 male B6C3F1 mice were obtained from the pathology data base of more than 300 long-term toxicity/carcinogenicity studies performed for the National Toxicology Program. The overall incidence of reproductive system neoplasms in male F344 rats was 81.5%. The most common neoplasms were interstitial cell adenoma of the testis (76.6%), adenoma/carcinoma of the preputial glands (2.9%), mesothelioma of the tunica vaginalis (1.5%), and adenoma of the prostate gland (0.3%). The combined incidence (0.1%) of 59 other rare neoplasms consisted of 18 different types that occurred with a frequency of 4 or less. In contrast to the rats, male B6C3F1 mice had a low overall incidence (0.6%) of neoplasms in reproductive organs. The most common neoplasm was the interstitial cell adenoma (0.4%). Thirty additional types of neoplasms were identified. Each of these uncommon neoplasms occurred at a frequency of 12 or less with an overall combined incidence of 0.2%. Morphological features are described for neoplasms in the rat and mouse, and criteria are presented for differentiation of testicular interstitial cell adenoma, prostatic adenoma, and mesothelioma from hyperplastic changes.
51230只雄性Fischer 344（F344）大鼠和46752只雄性B6C3F1小鼠睾丸及附属生殖器官所有原发性肿瘤的发生率，来自为国家毒理学计划开展的300多项长期毒性/致癌性研究的病理学数据库。雄性F344大鼠生殖系统肿瘤的总体发生率为81.5%。最常见的肿瘤为睾丸间质细胞瘤（76.6%）、包皮腺腺瘤/癌（2.9%）、鞘膜间皮瘤（1.5%）和前列腺腺瘤（0.3%）。其他59种罕见肿瘤的合并发生率为0.1%，由18种不同类型组成，其发生频率为4次及以下。与大鼠不同，雄性B6C3F1小鼠生殖器官肿瘤的总体发生率较低（0.6%）。最常见的肿瘤是间质细胞瘤（0.4%）。另外还鉴定出30种肿瘤类型。这些不常见肿瘤的发生频率均为12次及以下，总体合并发生率为0.2%。文中描述了大鼠和小鼠肿瘤的形态学特征，并给出了区分睾丸间质细胞瘤、前列腺腺瘤和间皮瘤与增生性改变的标准。
