Müller J, Skakkebaek N E, Parkinson M C
Int J Androl. 1987 Feb;10(1):147-56. doi: 10.1111/j.1365-2605.1987.tb00176.x.
The spermatocytic seminoma has clinical and histological characteristics which differ from those of other germ cell tumours of the testis. Classical seminomas and teratomas are believed to originate from intratubular carcinoma-in-situ (CIS), which is almost invariably found adjacent to these neoplasms. In addition, DNA analysis of these tumours and the surrounding CIS has shown both to have an aneuploid distribution. In order to throw light on the origin of the spermatocytic seminoma, we have examined the testicular tissue adjacent to fifteen spermatocytic seminomas for the presence of CIS and assessed the DNA content of the tumour cells densitometrically. In twelve specimens seminiferous tubules were present adjacent to the tumour, and in none of these cases was CIS seen. Nuclear DNA measurements were possible in eleven tumours and in five cases the distribution was diploid, in three cases tetraploid, and only in three cases aneuploid. Therefore, we suggest that the spermatocytic seminoma has a different cell of origin from that of other germ cell tumours of the testis.
精母细胞性精原细胞瘤具有与睾丸其他生殖细胞肿瘤不同的临床和组织学特征。经典型精原细胞瘤和畸胎瘤被认为起源于管内原位癌（CIS），几乎总是在这些肿瘤附近发现。此外，对这些肿瘤及其周围CIS的DNA分析显示二者均具有非整倍体分布。为了阐明精母细胞性精原细胞瘤的起源，我们检查了15例精母细胞性精原细胞瘤附近的睾丸组织中是否存在CIS，并通过密度测定法评估了肿瘤细胞的DNA含量。在12个标本中，肿瘤附近存在生精小管，且在这些病例中均未见到CIS。对11个肿瘤进行了核DNA测量，其中5例分布为二倍体，3例为四倍体，仅3例为非整倍体。因此，我们认为精母细胞性精原细胞瘤的起源细胞与睾丸其他生殖细胞肿瘤不同。
