Philpott D E, Sapp W, Miquel J, Kato K, Corbett R, Stevenson J, Black S, Lindseth K A, Benton E V
Scan Electron Microsc. 1985(Pt 3):1177-82.
Eight month old C57BL6 mice were exposed (head only) to 0.5 rad or 50 rads of Argon particles at the Lawrence Berkeley Radiation Facility, CA. Neuromotor performance was assessed monthly for six months beginning twelve weeks post-irradiation using a "string test". The decline in motor performance was dose-related and none of the animals was able to complete the task after four months of testing. Morphological changes were monitored six and twelve months post-irradiation by light and electron microscopy. The synaptic density in the CA-1 area of the hippocampus decreased six and twelve months after irradiation. The decrease after twelve months was less than after six months. The width of the outer nuclear layer (ONL) of the retina increased with increasing dose. The number of blood vessels between the ONL and the ganglion layer decreased twelve months after irradiation and this area did not show significant accumulation of age pigment.
8 个月大的 C57BL6 小鼠在加利福尼亚州劳伦斯伯克利辐射设施中仅头部暴露于 0.5 拉德或 50 拉德的氩粒子辐射下。从辐照后 12 周开始，每月使用“细绳测试”对神经运动性能进行为期六个月的评估。运动性能的下降与剂量相关，在测试四个月后没有一只动物能够完成任务。在辐照后 6 个月和 12 个月通过光学显微镜和电子显微镜监测形态学变化。海马体 CA-1 区的突触密度在辐照后 6 个月和 12 个月降低。12 个月后的降低幅度小于 6 个月后的降低幅度。视网膜外核层（ONL）的宽度随剂量增加而增加。辐照 12 个月后，ONL 和神经节层之间的血管数量减少，并且该区域未显示出明显的老年色素积累。
