Rovani Christine Anastasia, Marlina Erni, Liu Chung-Ming
Graduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, Taiwan.
Oral Medicine Department, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.
Dent J (Basel). 2025 Jul 10;13(7):310. doi: 10.3390/dj13070310.
Oral lichen planus (OLP) is a chronic autoimmune disorder affecting various age groups and is associated with multiple factors. Conventional therapies often encounter complications from opportunistic infections, particularly oral candidiasis. This study examines the relationships between colonization and oral microbiome composition in OLP patients. Through meta-analysis, we clarify these interactions and their implications for OLP progression. The PICOS is a systematic research strategy, following PRISMA 2020 and MeSH descriptors: oral lichen planus, oral microbiome, oral fungal, and non- oral fungal. A search of CINAHL, EMBASE, PubMed, Science Direct, and Web of Science identified 313 studies. Twelve studies were suitable for a systematic review, with four appropriate for meta-analysis. Findings showed a significant association between OLP and oral microbiota, with an OR of 4.155 (95% CI: 1.278-13.511, = 0.024). Although analyses of and non- species lacked significance, particular non- species were noted. The subgroup analysis of oral microbiota approached significance, indicated by an OR of 11.739 (95% CI: 0.654-210.713, = 0.059). This study highlights the roles of species and the oral microbiota in OLP, revealing a complex interaction between colonization and the oral microbiome.
口腔扁平苔藓（OLP）是一种影响各个年龄组的慢性自身免疫性疾病，与多种因素相关。传统疗法常常会遭遇机会性感染引发的并发症，尤其是口腔念珠菌病。本研究探讨了OLP患者中念珠菌定植与口腔微生物群组成之间的关系。通过荟萃分析，我们阐明了这些相互作用及其对OLP进展的影响。PICOS是一种遵循PRISMA 2020和医学主题词描述符的系统研究策略：口腔扁平苔藓、口腔微生物群、口腔真菌和非口腔真菌。对CINAHL、EMBASE、PubMed、Science Direct和Web of Science进行检索后，共识别出313项研究。12项研究适合进行系统评价，其中4项适合进行荟萃分析。研究结果显示，OLP与口腔微生物群之间存在显著关联，比值比为4.155（95%置信区间：1.278 - 13.511，P = 0.024）。尽管对念珠菌属和非念珠菌属的分析缺乏显著性，但注意到了特定的非念珠菌属。口腔微生物群的亚组分析接近显著性，比值比为11.739（95%置信区间：0.654 - 210.713，P = 0.059）。本研究突出了念珠菌属物种和口腔微生物群在OLP中的作用，揭示了念珠菌定植与口腔微生物群之间的复杂相互作用。
