Saraneva Orvokki, Furuholm Jussi, Hagström Jaana, Sorsa Timo, Rita Ville, Tervahartiala Taina, Välimaa Hannamari, Ruokonen Hellevi
Department of Oral and Maxillofacial Diseases, University of Helsinki, FI-00290 Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, Helsinki University Hospital and University of Helsinki, FI-00290 Helsinki, Finland.
Dent J (Basel). 2023 Jul 14;11(7):170. doi: 10.3390/dj11070170.
This retrospective study addressed the role of oral potentially malignant disorders and the presence of intraepithelial hyphae in the carcinogenesis of the oral tongue squamous cell carcinoma and its association with smoking, alcohol consumption, and oral inflammatory burden. The medical records of 183 subjects diagnosed with oral tongue squamous cell carcinoma at the Helsinki University Hospital were investigated. Preceding oral lichen planus, lichenoid reaction, and leukoplakia diagnosis were recorded. Further, the data on hyphae in histological samples as an indicator of oral candidiasis, oral inflammatory burden, smoking, and alcohol consumption were recorded and analyzed. The histopathological diagnosis of oral lichen planus/lichenoid reaction ( < 0.001) and the presence of hyphae ( = 0.005) were associated significantly with female gender. Oral lichen planus/lichenoid reaction patients were less often smokers than patients without these lesions. hyphae were more often recorded in patients without alcohol use ( = 0.012). Oral lichen planus/lichenoid reaction and hyphae in histological samples were associated with female gender and lower levels of typical risk factors, such as alcohol use and smoking, in oral tongue squamous cell carcinoma patients. Therefore, these patients should be well monitored despite a potential lack of the classical risk factors of oral carcinoma.
这项回顾性研究探讨了口腔潜在恶性疾病及上皮内菌丝的存在在口腔舌鳞状细胞癌发生过程中的作用，以及它们与吸烟、饮酒和口腔炎症负担的关联。对赫尔辛基大学医院诊断为口腔舌鳞状细胞癌的183名患者的病历进行了调查。记录了之前口腔扁平苔藓、苔藓样反应和白斑的诊断情况。此外，记录并分析了组织学样本中作为口腔念珠菌病指标的菌丝数据、口腔炎症负担、吸烟和饮酒情况。口腔扁平苔藓/苔藓样反应的组织病理学诊断（<0.001）和菌丝的存在（=0.005）与女性性别显著相关。与没有这些病变的患者相比，口腔扁平苔藓/苔藓样反应患者吸烟的频率较低。在不饮酒的患者中更常记录到菌丝（=0.012）。口腔扁平苔藓/苔藓样反应和组织学样本中的菌丝与口腔舌鳞状细胞癌患者的女性性别以及较低水平的典型风险因素（如饮酒和吸烟）相关。因此，尽管这些患者可能缺乏口腔癌的经典风险因素，但仍应受到密切监测。
