Palankalieva Antonia, Katsarov Plamen, Belcheva Ani
Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University of Plovdiv, 3 Hristo Botev Blvd, 4000 Plovdiv, Bulgaria.
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Dent J (Basel). 2025 Jul 21;13(7):331. doi: 10.3390/dj13070331.
: Early caries management is essential to enable reversal of white spot lesions without the further need for operative interventions, especially in primary dentition. Silver-based compounds can be quite effective in arresting caries lesions; however, a major drawback is teeth staining. This study aimed to evaluate the remineralization potential and aesthetic effects of novel, green-synthesized nano-silver fluoride (NSF) on artificial white spot lesions in primary teeth in comparison to 38% silver diamine fluoride (SDF) and silver diamine fluoride/potassium iodide (SDF/KI). : NSF was synthesized using green tea extract. Sixty primary teeth specimens with artificial enamel lesions were randomly divided into five groups depending on the applied material: 38% SDF, 38% SDF/KI, single and double application of NSF, and control group. Treatments were followed by pH cycling. Surface microhardness and photographic analysis were conducted to assess remineralization and staining. Statistical analysis was conducted using non-parametric tests including Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction. : The greatest increase in microhardness was observed in the group receiving double NSF application. Its remineralizing potential was comparable to that of 38% SDF/KI, with no statistically significant difference ( = 1.000). Importantly, NSF-treated samples exhibited no teeth discoloration, unlike the black staining observed in SDF and SDF/KI groups. : Green-synthesized NSF is a promising alternative to conventional SDF and SDF/KI, offering remineralization benefits without compromising aesthetics. The eco-friendly formulation and non-staining properties support its potential for clinical use in pediatric dentistry.
早期龋齿管理对于实现白斑病变的逆转至关重要，无需进一步进行手术干预，尤其是在乳牙列中。银基化合物在阻止龋齿病变方面可能相当有效；然而，一个主要缺点是牙齿染色。本研究旨在评估新型绿色合成纳米氟化银（NSF）与38%氟化亚锡（SDF）和氟化亚锡/碘化钾（SDF/KI）相比，对乳牙人工白斑病变的再矿化潜力和美学效果。：NSF使用绿茶提取物合成。60颗有人造釉质病变的乳牙标本根据应用材料随机分为五组：38% SDF、38% SDF/KI、单次和双次应用NSF以及对照组。处理后进行pH循环。进行表面显微硬度和摄影分析以评估再矿化和染色情况。使用非参数检验进行统计分析，包括Kruskal-Wallis检验和Mann-Whitney U检验，并进行Bonferroni校正。：在接受双次NSF应用的组中观察到显微硬度增加最大。其再矿化潜力与38% SDF/KI相当，无统计学显著差异（ = 1.000）。重要的是，与SDF和SDF/KI组中观察到的黑色染色不同，经NSF处理的样本未出现牙齿变色。：绿色合成的NSF是传统SDF和SDF/KI的有前途的替代品，在不影响美观的情况下提供再矿化益处。其环保配方和无染色特性支持其在儿童牙科临床应用的潜力。
