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急性髓系白血病异基因干细胞移植中基于放疗和烷化剂的预处理治疗方案比较：临床医生视角

A Comparison of Radiation and Alkylator-Based Conditioning Therapy Regimens for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Clinician's Perspective.

作者信息

Marinos Velarde Alejandro, Alvarenga Thiebaud Julio, Madanat Yazan, Toor Amir

机构信息

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Curr Oncol. 2025 Jul 1;32(7):381. doi: 10.3390/curroncol32070381.

DOI:10.3390/curroncol32070381
PMID:40710192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12293537/
Abstract

Despite significant advancements in the treatment of acute myeloid leukemia (AML), hematopoietic stem cell transplantation (HSCT) remains the only curative option for patients with primary refractory AML, those with relapsed disease and for patients who are in first complete remission where the disease has high risk cytogenetic and/or molecular features that increase relapse risk [...].

摘要

尽管急性髓系白血病（AML）的治疗取得了重大进展，但造血干细胞移植（HSCT）仍然是原发性难治性AML患者、复发疾病患者以及首次完全缓解但疾病具有高风险细胞遗传学和/或分子特征且增加复发风险的患者的唯一治愈选择[……]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce6/12293537/5801977b23e1/curroncol-32-00381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce6/12293537/0503a7b70e1c/curroncol-32-00381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce6/12293537/5801977b23e1/curroncol-32-00381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce6/12293537/0503a7b70e1c/curroncol-32-00381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ce6/12293537/5801977b23e1/curroncol-32-00381-g002.jpg

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本文引用的文献

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Randomized Phase III SIERRA Trial of I-Apamistamab Before Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care for Relapsed/Refractory AML.异基因造血细胞移植前使用I-阿帕米司他单抗对比传统治疗方案治疗复发/难治性急性髓系白血病的随机III期SIERRA试验
J Clin Oncol. 2025 Jan 10;43(2):201-213. doi: 10.1200/JCO.23.02018. Epub 2024 Sep 19.
2
Total Body Irradiation and Fludarabine with Post-Transplantation Cyclophosphamide for Mismatched Related or Unrelated Donor Hematopoietic Cell Transplantation.全身照射和氟达拉滨联合移植后环磷酰胺治疗不合血缘相关或无关供者造血细胞移植。
Transplant Cell Ther. 2024 Oct;30(10):1013.e1-1013.e12. doi: 10.1016/j.jtct.2024.08.005. Epub 2024 Aug 8.
3
Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients.
在复发急性髓系白血病患者中，第二次异基因造血干细胞移植后时间推移的结局持续改善：一项来自 EBMT 注册分析的 1540 例患者研究。
Blood Cancer J. 2024 May 2;14(1):76. doi: 10.1038/s41408-024-01060-4.
4
Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial.复发或反应不佳的急性髓系白血病患者的缓解诱导与立即进行异基因造血干细胞移植（ASAP）：一项随机、开放标签、3期、非劣效性试验。
Lancet Haematol. 2024 May;11(5):e324-e335. doi: 10.1016/S2352-3026(24)00065-6. Epub 2024 Apr 4.
5
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