Cialdai Francesca, Brown Austin M, Baumann Cory W, Angeloni Debora, Baatout Sarah, Benchoua Alexandra, Bereiter-Hahn Juergen, Bottai Daniele, Buchheim Judith-Irina, Calvaruso Marco, Carnero-Diaz Eugénie, Castiglioni Sara, Cavalieri Duccio, Ceccarelli Gabriele, Choukér Alexander, Ciofani Gianni, Coppola Giuseppe, Cusella Gabriella, Degl'Innocenti Andrea, Desaphy Jean-Francois, Frippiat Jean-Pol, Gelinsky Michael, Genchi Giada, Grano Maria, Grimm Daniela, Guignandon Alain, Hahn Christiane, Hatton Jason, Herranz Raúl, Hellweg Christine E, Iorio Carlo Saverio, Karapantsios Thodoris, van Loon Jack, Lulli Matteo, Maier Jeanette, Malda Jos, Mamaca Emina, Morbidelli Lucia, van Ombergen Angelique, Osterman Andreas, Ovsianikov Aleksandr, Pampaloni Francesco, Pavezlorie Elizabeth, Pereda-Campos Veronica, Przybyla Cyrille, Puhl Christopher, Rettberg Petra, Risaliti Chiara, Rizzo Angela Maria, Robson-Brown Kate, Rossi Leonardo, Russo Giorgio, Salvetti Alessandra, Santucci Daniela, Sperl Matthias, Strollo Felice, Tabury Kevin, Tavella Sara, Thielemann Christiane, Willaert Ronnie, Szewczyk Nathaniel J, Monici Monica
ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy.
Honors Tutorial College, Ohio University, Athens, OH, USA.
NPJ Microgravity. 2023 Oct 21;9(1):84. doi: 10.1038/s41526-023-00330-y.
The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: "How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?" This is one of the five major scientific issues of the ESA roadmap "Biology in Space and Analogue Environments". Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.
本白皮书涉及科学空间科学共同体的指示和建议，旨在填补知识空白，以回答“重力变化如何在细胞/组织水平上影响动物和人类系统？”这一问题。这是欧洲航天局路线图“空间及模拟环境中的生物学”的五大主要科学问题之一。尽管迄今为止已经对航天适应机制以及宇航员中观察到的相关病理生理变化进行了许多研究，但我们仍无法构建一个综合模型来阐述在不同系统和功能水平上发生的众多变化。因此，难以开发可靠的模型来预测人类适应太空环境的长期后果，也难以实施长期任务的医疗支持计划以及预防因长时间暴露于低地球轨道（LEO）以外的太空飞行而可能产生的健康风险的策略。科学界建议的研究活动旨在通过努力以更全面的太空适应效应视角将生物学和生理学方面联系起来，来克服这些问题。
