Kanaujia Kunal Agam, Wagh Suraj, Pandey Giriraj, Phatale Vivek, Khairnar Pooja, Kolipaka Tejaswini, Rajinikanth P S, Saraf Shubhini A, Srivastava Saurabh, Kumar Shailendra
Institute of Pharmacy, Dr Rammanohar Lohia Avadh University, Ayodhya, Uttar Pradesh 224133, India.
Pharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Int J Biol Macromol. 2025 May;307(Pt 3):142158. doi: 10.1016/j.ijbiomac.2025.142158. Epub 2025 Mar 17.
Marine antimicrobial peptides (AMPs) are potent bioactive compounds with broad-spectrum activity against bacteria, viruses, and fungi, offering a promising alternative to traditional antibiotics. These small, cationic, and amphiphilic peptides (3-50 amino acids) are key components of marine organisms' immune defenses, adapted to harsh oceanic environments. Discovered in the 1980s, marine AMPs have garnered interest for their unique structures and potential applications in human health. However, despite the ocean's vast biodiversity, they remain underexplored compared to land-based AMPs. This review emphasizes the therapeutic potential of marine AMPs, including their modes of action, structural variety, and applications in drug development, tissue regeneration, and cancer treatment. Moreover, it discusses their antibacterial, antiviral, antifungal, and antiparasitic properties. Additionally, the review addresses strategies to enhance the therapeutic potential of marine AMPs and the challenges associated with their development. By examining the promising future of marine AMPs, this review aims to pave the way for new approaches to combat antimicrobial resistance and develop innovative treatments for various infectious diseases. The potential of marine AMPs as the "medicine bank of the new millennium" remains vast, providing a valuable resource for future drug discovery and sustainable practices across industries.
海洋抗菌肽（AMPs）是具有广谱活性的强效生物活性化合物，对细菌、病毒和真菌均有作用，为传统抗生素提供了一种有前景的替代方案。这些小的、阳离子型且具有两亲性的肽（3 - 50个氨基酸）是海洋生物免疫防御的关键组成部分，适应于恶劣的海洋环境。海洋抗菌肽于20世纪80年代被发现，因其独特的结构以及在人类健康方面的潜在应用而受到关注。然而，尽管海洋具有丰富的生物多样性，但与陆地来源的抗菌肽相比，它们仍未得到充分探索。本综述强调了海洋抗菌肽的治疗潜力，包括其作用方式、结构多样性以及在药物开发、组织再生和癌症治疗中的应用。此外，还讨论了它们的抗菌、抗病毒、抗真菌和抗寄生虫特性。另外，该综述阐述了提高海洋抗菌肽治疗潜力的策略以及与其开发相关的挑战。通过审视海洋抗菌肽充满希望的未来，本综述旨在为对抗抗菌耐药性的新方法以及开发针对各种传染病的创新治疗方法铺平道路。海洋抗菌肽作为“新千年的药库”的潜力仍然巨大，为未来药物发现和各行业的可持续发展实践提供了宝贵资源。
