黑腹果蝇中合子致死基因纯合的体细胞行为。
Behavior of somatic cells homozygous for zygotic lethals in Drosophila melanogaster.
作者信息
Ripoll P
出版信息
Genetics. 1977 Jun;86(2 Pt. 1):357-76.
Abstract
The behavior in genetic mosaics of 86 EMS-induced sex-linked lethals has been studied. Seventy-five percent of them are autonomous in gynandromorphs. Forty-three lethals nonviable in sex mosaics have been analyzed in X-ray-induced spots in the abdominal tergites and the imaginal wing derivatives. Of the lethals, 90.7% are homozygous viable in mosaic spots, and only 9.3% have been classified as epidermal cell lethal. Thus, the fraction of the Drosophila genome essential for cell viability has been estimated to be about 420 genes. The phenotypes at the cellular level of some cell-viable mutations altering cell parameters (mitotic orientation, differentiation, etc.) are described.
摘要
对86个经乙基亚硝基脲（EMS）诱导产生的性连锁致死基因在基因嵌合体中的行为进行了研究。其中75%在雌雄嵌合体中是自主的。已对43个在性嵌合体中无活力的致死基因在腹部背板和成虫翅衍生物的X射线诱导斑中进行了分析。在这些致死基因中，90.7%在嵌合斑中纯合存活，只有9.3%被归类为表皮细胞致死基因。因此，据估计果蝇基因组中对细胞活力至关重要的部分约为420个基因。描述了一些改变细胞参数（有丝分裂方向、分化等）的细胞存活突变在细胞水平上的表型。
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