Portin P
Genetics. 1977 Jun;86(2 Pt. 1):309-19.
Certain Abruptex alleles in the Notch pseudoallelic series of Drosophila melanogaster show strong negative complementation. Heterozygous combinations of some viable alleles are lethal. As a lethal system this is unique. Analysis of this type of allelic interaction in gynandromorphs suggests that the lethal focus has a fate-map site in the anterior part of the fly, probably close to the central part of the thorax. In addition to the lethal effect, negative interaction of the alleles can also be seen in the morphological level, the negative interaction of the alleles can also be seen in the morphogenesis of wings and chaetae of thorax and head. At this morphological level, the negative interaction of the alleles appears to be autonomous.
果蝇黑腹果蝇Notch拟等位基因系列中的某些Abruptex等位基因表现出强烈的负互补作用。一些可行等位基因的杂合组合是致死的。作为一种致死系统,这是独一无二的。对雌雄嵌合体中这种等位基因相互作用类型的分析表明,致死位点在果蝇前部有一个命运图谱位点,可能靠近胸部中央部分。除了致死效应外,等位基因的负相互作用在形态学水平上也可见,在胸部和头部的翅膀和刚毛的形态发生中也可见等位基因的负相互作用。在这个形态学水平上,等位基因的负相互作用似乎是自主的。