Bhatti Rohail, Sato Priscila Y
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Physiol. 2024 Apr 5;15:1357285. doi: 10.3389/fphys.2024.1357285. eCollection 2024.
Cell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed. Unbalanced cell death can lead to uncontrolled cell proliferation (i.e., tumors) or excessive loss of cells (i.e., ischemia injury tissue loss). Thus, it is imperative for modes of cell death to be balanced and controlled. Here, we will focus on a recent mode of cell death called pyroptosis. While extensive studies have shown the role of this route of cell death in macrophages and monocytes, evidence for pyroptosis have expanded to encompass other pathologies, including cancer and cardiac diseases. Herein, we provide a brief review on pyroptosis and discuss current gaps in knowledge and scientific advances in cardiac pyroptosis in recent years. Lastly, we provide conclusions and prospective on the relevance to various cardiac diseases.
细胞死亡是一种重要的细胞机制，可确保质量控制和全身稳态。人们已经对各种细胞死亡模式进行了研究并详细阐述。细胞死亡失衡会导致细胞不受控制地增殖（即肿瘤）或细胞过度损失（即缺血性损伤组织损失）。因此，细胞死亡模式必须保持平衡并受到控制。在此，我们将重点关注一种名为细胞焦亡的最新细胞死亡模式。虽然广泛的研究已经表明这种细胞死亡途径在巨噬细胞和单核细胞中的作用，但细胞焦亡的证据已扩展到包括癌症和心脏病在内的其他病理情况。在此，我们简要综述细胞焦亡，并讨论近年来心脏细胞焦亡方面目前的知识空白和科学进展。最后，我们就其与各种心脏疾病的相关性给出结论和展望。
