Rabelink Ton J, Hosgood Sarah, Minor Thomas, Selzner Markus, Weissenbacher Annemarie, Leuvenink Henri Gd, Schneeberger Stefan
Department of Medicine and Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.
Department of Surgery, University of Cambridge. Addenbrooke's Hospital. Level 9. CB2 0QQ, Cambridge, UK.
Nat Commun. 2025 Jul 25;16(1):6883. doi: 10.1038/s41467-025-60410-3.
End stage kidney disease and dialysis are lifetime limiting and lifestyle-defining conditions with enormous costs to the health care system. Despite a severe organ shortage, thousands of organs that are retrieved for transplantation go to waste every year because of the presumed inadequacy of organ quality and/or the limited organ preservation time. Normothermic kidney machine perfusion (NMP) holds the potential to resolve this through improved preservation, prolonged preservation time, kidney quality assessment, reconditioning and treatment. We herein develop a perspective on the potential, but also the hurdles towards the breakthrough of this technology.
终末期肾病和透析是限制生命且定义生活方式的病症，给医疗保健系统带来巨大成本。尽管器官严重短缺，但由于假定的器官质量不足和/或器官保存时间有限，每年数千个获取用于移植的器官被浪费。常温肾脏机器灌注（NMP）有潜力通过改善保存、延长保存时间、肾脏质量评估、修复和治疗来解决这一问题。我们在此阐述了这项技术取得突破的潜力以及面临的障碍。
