Li Chao, Yang Fan, Gong WeiFen
Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong Province, PR China.
Photodiagnosis Photodyn Ther. 2025 Jul 25;55:104733. doi: 10.1016/j.pdpdt.2025.104733.
To evaluate the efficacy of Highly Aspherical Lenslets (HAL) in slowing myopia progression among schoolchildren and compare it to orthokeratology.
This retrospective study included 475 myopic patients aged 6 to 15 years, with myopia ranging from -0.75 to -5.75D Only the right eye of each subject was analyzed. Cycloplegic refraction and axial length(AL) measurements were performed at baseline and after 6 months (only AL measurements were performed in the orthokeratology group after 6 months).
After 6 months, HAL lenses(0.00 [-0.25,0.00]D) significantly delayed spherical equivalent refraction (SER) myopia progression compared to single vision (SV) lenses(-0.50 [-0.75,-0.25]D) in both low and moderate myopia(P < 0.001). Additionally, both HAL (0.06 ± 0.10 mm) and orthokeratology(0.04 ± 0.13 mm) lenses significantly reduced AL elongation compared to SV lenses(0.25 ± 0.16 mm, (P < 0.001). However, there was no statistical difference between HAL and orthokeratology lenses in AL elongation(P = 0.157). In the low myopia group, HAL(0.05 ± 0.12 mm) and orthokeratology(0.09 ± 0.15 mm) lenses both significantly slowed AL elongation compared to SV lenses (0.27 ± 0.17 mm, P < 0.001), with HAL lenses showing a slight advantage over orthokeratology lenses(P = 0.038). In the moderate myopia group, both HAL(0.07 ± 0.09 mm) and orthokeratology(0 ± 0.10 mm) lenses significantly delayed AL elongation compared to SV lenses(0.22 ± 0.14 mm), with orthokeratology lenses having a stronger effect than HAL lenses(P < 0.001).
HAL lenses demonstrate superior efficacy to SV lenses in mitigating myopia progression in both low and moderate myopia. Both HAL and orthokeratology lenses are effective in reducing AL elongation. Specifically, HAL lenses exhibit greater effectiveness in decreasing AL elongation in cases of low myopia, whereas Ortho-K lenses show a pronounced advantage in managing AL elongation in moderate myopia.
评估高非球面微透镜（HAL）减缓学龄儿童近视进展的疗效，并将其与角膜塑形术进行比较。
这项回顾性研究纳入了475名6至15岁的近视患者，近视度数在-0.75至-5.75D之间。仅分析每个受试者的右眼。在基线时以及6个月后进行睫状肌麻痹验光和眼轴长度（AL）测量（角膜塑形术组在6个月后仅进行AL测量）。
6个月后，在低度和中度近视中，与单焦点（SV）镜片（-0.50 [-0.75, -0.25]D）相比，HAL镜片（0.00 [-0.25, 0.00]D）显著延缓了等效球镜度（SER）近视进展（P < 0.001）。此外，与SV镜片（0.25 ± 0.16 mm）相比，HAL镜片（0.06 ± 0.10 mm）和角膜塑形术镜片（0.04 ± 0.13 mm）均显著降低了眼轴伸长（P < 0.001）。然而，HAL镜片和角膜塑形术镜片在眼轴伸长方面无统计学差异（P = 0.157）。在低度近视组中，与SV镜片（0.27 ± 0.17 mm）相比，HAL镜片（0.05 ± 0.12 mm）和角膜塑形术镜片（0.09 ± 0.15 mm）均显著减缓了眼轴伸长（P < 0.001），HAL镜片比角膜塑形术镜片略有优势（P = 0.038）。在中度近视组中，与SV镜片（0.22 ± 0.14 mm）相比，HAL镜片（0.07 ± 0.09 mm）和角膜塑形术镜片（0 ± 0.10 mm）均显著延缓了眼轴伸长，角膜塑形术镜片的效果比HAL镜片更强（P < 0.001）。
在低度和中度近视中，HAL镜片在减轻近视进展方面显示出优于SV镜片的疗效。HAL镜片和角膜塑形术镜片在减少眼轴伸长方面均有效。具体而言，HAL镜片在低度近视病例中降低眼轴伸长方面表现出更大的有效性，而角膜塑形术镜片在控制中度近视的眼轴伸长方面显示出明显优势。
