Shi Yushan, Huang Di, Qu Linlin, Liu Qingyin, Qiu Zhanjun, Chen Xianhai
Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of laboratory, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
PLoS One. 2025 Jul 28;20(7):e0327877. doi: 10.1371/journal.pone.0327877. eCollection 2025.
Relatively few studies have investigated the link between the Life's Essential 8 (LE8) score and depression among individuals with Chronic Obstructive Pulmonary Disease (COPD). Our objective was to explore the potential association between the LE8 score and the presence of depression in adults aged ≥40 years who diagnosed with COPD.
Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2018 was used in this study. Weighted logistic regressions, restricted cubic splines (RCS) were utilized to investigate the correlation between LE8 score and depression. Using a two-piecewise logistic regression model to identify potential threshold effects. Subgroups and sensitivity analyses were conducted to test the robust of the association.
The study encompassed a total of 1,110 subjects diagnosed with COPD. In fully adjusted statistical model, an increment of 10 points in the LE8 score was correlated with a reduced likelihood of depression (OR: 0.68, 95% CI: 0.58-0.78). Similar trends in the associations of health behavior score (OR = 0.75, 95% CI: 0.67-0.84) with depression was also identified. The threshold for the LE8 score was pinpointed at 50.0; surpassing this value, the probability of depression decreased by 8.0% for each additional point in the LE8 score (OR, 0.92; 95% CI: 0.88-0.95; P < 0.001). Furthermore, higher LE8 metric scores of physical activity, nicotine exposure and sleep health were associated with a lower prevalence of depression. The results of subgroup and sensitivity analyses were found to be consistent with the principal analysis.
There is a non-linear relationship between LE8 score and depression, with an inflection point of roughly 50.0. Adhering to a higher LE8 score (≥50.0) was correlated with lower odds of depression among COPD adults aged ≥ 40years.
相对较少的研究探讨了慢性阻塞性肺疾病（COPD）患者的生命基本八项（LE8）评分与抑郁症之间的联系。我们的目的是探讨LE8评分与≥40岁诊断为COPD的成年人抑郁症存在之间的潜在关联。
本研究使用了2005年至2018年美国国家健康与营养检查调查（NHANES）的数据。采用加权逻辑回归、受限立方样条（RCS）来研究LE8评分与抑郁症之间的相关性。使用两段式逻辑回归模型来识别潜在的阈值效应。进行亚组分析和敏感性分析以检验该关联的稳健性。
该研究共纳入1110名诊断为COPD的受试者。在完全调整的统计模型中，LE8评分每增加10分与抑郁症可能性降低相关（OR：0.68，95%CI：0.58 - 0.78）。健康行为评分与抑郁症的关联也呈现类似趋势（OR = 0.75，95%CI：0.67 - 0.84）。LE8评分的阈值确定为50.0；超过该值，LE8评分每增加1分，抑郁症的概率降低8.0%（OR，0.92；95%CI：0.88 - 0.95；P < 0.001）。此外，身体活动、尼古丁暴露和睡眠健康的LE8指标得分较高与抑郁症患病率较低相关。亚组分析和敏感性分析的结果与主要分析一致。
LE8评分与抑郁症之间存在非线性关系，拐点约为50.0。坚持较高的LE8评分（≥50.0）与≥40岁COPD成年人患抑郁症的几率较低相关。
