Department of Neurosurgery, the Third Xiangya Hospital, Central South University, Hunan, China.
Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Psychiatry Res. 2024 Aug;338:115986. doi: 10.1016/j.psychres.2024.115986. Epub 2024 Jun 1.
Few studies have examined the association of Life's Essential 8 (LE8) with depression among US adults. This is a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020. LE8 score was measured as the mean score of eight metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipid, blood glucose, and blood pressure). CVH was categorized into low, moderate, and high according to tertiles of LE8 score. Depression was defined based on the 9-Item Patient Health Questionnaire (PHQ-9). Weighted logistic regressions were conducted to assess the associations of depression with CVH. Compared with participants with low CVH, the fully adjusted ORs of depression were 0.45 (0.37, 0.55) in the moderate CVH and 0.21 (0.15, 0.30) in the high CVH participants, respectively. The results remained robust in subgroup and sensitivity analyses. All eight LE8 metrics were negatively associated with depression, while nicotine exposure and sleep health were identified as two major metrics contributing to the association. Better CVH evaluated by LE8 was associated with decreased depression prevalence among US adults. Adherence to a higher CVH score, especially targeting smoking cessation and proper sleep duration, might be beneficial for prevention of depression.
很少有研究探讨美国成年人的生活必需 8 项指标（LE8）与抑郁之间的关系。本研究是一项使用 2011-2020 年国家健康与营养调查（NHANES）数据进行的横断面研究。LE8 评分是通过 8 项指标（饮食、体力活动、尼古丁暴露、睡眠健康、体重指数、血脂、血糖和血压）的平均评分来衡量的。根据 LE8 评分的三分位数，将 CVH 分为低、中、高。抑郁是根据 9 项患者健康问卷（PHQ-9）来定义的。采用加权 logistic 回归来评估抑郁与 CVH 的关联。与低 CVH 参与者相比，中 CVH 参与者的抑郁完全调整后的 OR 为 0.45（0.37，0.55），高 CVH 参与者的抑郁完全调整后的 OR 为 0.21（0.15，0.30）。亚组和敏感性分析的结果仍然稳健。LE8 的所有 8 项指标均与抑郁呈负相关，而尼古丁暴露和睡眠健康被确定为与这种关联有关的两个主要指标。LE8 评估的更好的 CVH 与美国成年人中抑郁患病率的降低有关。遵循更高的 CVH 评分，特别是针对戒烟和适当的睡眠时间，可能有助于预防抑郁。
