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Finding the Four-Leaf CLOVERS: Biologic Subphenotypes and Fluid Tolerance in Sepsis.

作者信息

Kitsios Georgios D, Bhavani Sivasubramanium V, Shah Faraaz A

机构信息

Department of Medicine University of Pittsburgh Pittsburgh, Pennsylvania.

Acute Lung Injury and Infection Center of Excellence University of Pittsburgh Pittsburgh, Pennsylvania.

出版信息

Am J Respir Crit Care Med. 2025 Sep;211(9):1549-1551. doi: 10.1164/rccm.202506-1390ED.

DOI:10.1164/rccm.202506-1390ED
PMID:40720865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432389/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f85/12432389/6fb9ba1b7faa/rccm.202506-1390EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f85/12432389/6fb9ba1b7faa/rccm.202506-1390EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f85/12432389/6fb9ba1b7faa/rccm.202506-1390EDf1.jpg

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本文引用的文献

1
Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation.脓毒症的分子表型分析及对液体复苏的差异反应
Am J Respir Crit Care Med. 2025 Sep;211(9):1681-1688. doi: 10.1164/rccm.202412-2377OC.
2
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Ann Am Thorac Soc. 2025 Sep;22(9):1382-1393. doi: 10.1513/AnnalsATS.202501-012OC.
3
Clinician Prediction of Hyperinflammatory Acute Respiratory Distress Syndrome Subphenotypes: Overestimated but Prognostic.
临床医生对高炎症性急性呼吸窘迫综合征亚表型的预测：虽有高估但具有预后价值。
Am J Respir Crit Care Med. 2025 Jul;211(7):1294-1297. doi: 10.1164/rccm.202409-1816RL.
4
Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials.早期目标导向治疗对感染性休克疗效的异质性：两项多中心国际试验的二次分析
Crit Care Med. 2025 Jan 1;53(1):e4-e14. doi: 10.1097/CCM.0000000000006463. Epub 2024 Oct 23.
5
The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol.《脓毒症晶体液精准复苏（PRECISE）试验：试验方案》。
JAMA Netw Open. 2024 Sep 3;7(9):e2434197. doi: 10.1001/jamanetworkopen.2024.34197.
6
Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.利用 ProCESS 随机试验中的蛋白质生物标志物和临床数据鉴定高炎症性败血症表型。
Sci Rep. 2024 Mar 14;14(1):6234. doi: 10.1038/s41598-024-55667-5.
7
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.鉴定脓毒症的分子表型：两项前瞻性观察队列研究的分析和两项随机对照试验的二次分析。
Lancet Respir Med. 2023 Nov;11(11):965-974. doi: 10.1016/S2213-2600(23)00237-0. Epub 2023 Aug 23.
8
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