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血液和复层上皮细胞中的克隆及其驱动因素。

Clones in blood and stratified epithelial cells, and their drivers.

作者信息

Chiba Shigeru

机构信息

Institute of Medicine, University of Tsukuba.

Division of Hematology, Mito Saiseikai General Hospital.

出版信息

Proc Jpn Acad Ser B Phys Biol Sci. 2025;101(7):394-413. doi: 10.2183/pjab.101.026.

DOI:10.2183/pjab.101.026
PMID:40721380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12462364/
Abstract

The term "clone" is commonly used in the medical and life sciences to denote a genetically identical population, at both the individual and cellular levels. The concept of clonal expansion is of fundamental importance in cancer research. The advent of advanced sequencing technologies has elucidated the clonal nature of intermediates between normal cells and cancer cells. This review underscores seminal discoveries in the blood and stratified squamous epithelial systems, emphasizing the pivotal role of mutations in DNA modifier genes and Notch pathway genes, respectively, as drivers of clonal expansion. Despite the distinct nature of these systems and their genetic backgrounds, a common biological principle emerges.

摘要

“克隆”一词在医学和生命科学中通常用于表示个体和细胞水平上基因相同的群体。克隆扩增的概念在癌症研究中至关重要。先进测序技术的出现阐明了正常细胞和癌细胞之间中间体的克隆性质。本综述强调了血液和分层鳞状上皮系统中的开创性发现，分别强调了DNA修饰基因和Notch信号通路基因中的突变作为克隆扩增驱动因素的关键作用。尽管这些系统具有不同的性质和遗传背景，但一个共同的生物学原理还是显现出来了。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/cd726b79341c/pjab-101-394-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/d65e0905c466/pjab-101-394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/05c7033ca532/pjab-101-394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/da03e2374efe/pjab-101-394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/238117f895ce/pjab-101-394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/0ac22d04650a/pjab-101-394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/2b137574059d/pjab-101-394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/a020b5b7e4a2/pjab-101-394-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/5da398b5a558/pjab-101-394-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/cd726b79341c/pjab-101-394-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/d65e0905c466/pjab-101-394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/05c7033ca532/pjab-101-394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/da03e2374efe/pjab-101-394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/238117f895ce/pjab-101-394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/0ac22d04650a/pjab-101-394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/2b137574059d/pjab-101-394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/a020b5b7e4a2/pjab-101-394-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/5da398b5a558/pjab-101-394-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803b/12462364/cd726b79341c/pjab-101-394-g009.jpg

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本文引用的文献

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Nat Rev Cardiol. 2024 Nov;21(11):741. doi: 10.1038/s41569-024-01081-3.
2
The Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review.皮肤鳞状细胞癌的突变和微环境格局：综述
Cancers (Basel). 2024 Aug 21;16(16):2904. doi: 10.3390/cancers16162904.
3
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.
在人类克隆性造血中，突变干细胞的选择优势与对炎症和衰老的反应减弱有关。
Cell Stem Cell. 2024 Aug 1;31(8):1127-1144.e17. doi: 10.1016/j.stem.2024.05.010. Epub 2024 Jun 24.
4
Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells.克隆性造血相关 TET2 功能丧失会阻碍造血干细胞和祖细胞中 IL1β 介导的表观遗传重编程。
Nat Commun. 2023 Dec 7;14(1):8102. doi: 10.1038/s41467-023-43697-y.
5
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu's arteritis, ANCA-associated vasculitis and giant cell arteritis.在 Takayasu 动脉炎、抗中性粒细胞胞浆抗体相关性血管炎和巨细胞动脉炎的血管炎患者年龄谱中出现的克隆性造血。
Ann Rheum Dis. 2024 Mar 12;83(4):508-517. doi: 10.1136/ard-2023-224933.
6
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution.单细胞分辨率下的肿瘤异质性和免疫逃逸性T滤泡细胞淋巴瘤表型
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7
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8
Evolutionary histories of breast cancer and related clones.乳腺癌及其相关克隆的进化史。
Nature. 2023 Aug;620(7974):607-614. doi: 10.1038/s41586-023-06333-9. Epub 2023 Jul 26.
9
Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.在接受促红细胞生成素刺激剂治疗的、输血依赖的、低危骨髓增生异常综合征患者中，luspatercept 对比 epoetin alfa 的疗效和安全性（COMMANDS）：一项 3 期、开放标签、随机对照临床试验的中期分析。
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