Mouseli Ali, Shahrokhi Pejman, Sharafi Mehdi, Mastaneh Zahra, Gharibzadeh Abdollah, Jamali Leila, Shekari Arash
Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Department of Internal Medicine,Faculty of Medicine , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Sci Rep. 2025 Jul 28;15(1):27416. doi: 10.1038/s41598-025-13058-4.
Smoking is a significant modifiable risk factor influencing various health outcomes, including hematologic indices. This study investigates the association between smoking status and latent classes of complete blood count (CBC) profiles in older adults. Data were analyzed from the baseline phase of the Bandar Kong Cohort Study, including adults aged ≥ 35 years. Latent class analysis (LCA) was employed to identify subgroups based on CBC indices. Logistic regression was applied to examine associations between smoking status and class membership, adjusting for potential confounders. Four latent classes were identified: Class 1 (microcytic normochromic anemia; prevalence: 39.3%), Class 2 (beta-thalassemia minor; 13.8%), Class 3 (iron deficiency anemia; 34.4%), and Class 4 (mixed anemia; 12.5%). Current smoking was significantly associated with higher odds of membership in Class 2 (OR = 1.51, 95% CI = 1.05-2.16) and Class 4 (OR = 1.50, 95% CI = 1.08-2.10) compared to Class 1. Former smoking showed no significant associations. Smoking is significantly associated with specific CBC profiles, particularly beta-thalassemia minor and mixed anemia. These findings underscore the importance of considering smoking history in anemia diagnosis and management while highlighting the potential benefits of smoking cessation in mitigating adverse hematologic effects.
吸烟是一个重要的可改变风险因素，会影响包括血液学指标在内的各种健康结果。本研究调查了老年人吸烟状况与全血细胞计数（CBC）谱潜在类别之间的关联。对 Bandar Kong 队列研究基线阶段的数据进行了分析，包括年龄≥35 岁的成年人。采用潜在类别分析（LCA）根据 CBC 指标识别亚组。应用逻辑回归分析来检验吸烟状况与类别归属之间的关联，并对潜在混杂因素进行调整。确定了四个潜在类别：类别 1（小细胞正色素性贫血；患病率：39.3%）、类别 2（轻型β地中海贫血；13.8%）、类别 3（缺铁性贫血；34.4%）和类别 4（混合性贫血；12.5%）。与类别 1 相比，当前吸烟与类别 2（比值比[OR]=1.51，95%置信区间[CI]=1.05 - 2.16）和类别 4（OR = 1.50，95% CI = 1.08 - 2.10）的成员资格较高的几率显著相关。既往吸烟未显示出显著关联。吸烟与特定的 CBC 谱显著相关，尤其是轻型β地中海贫血和混合性贫血。这些发现强调了在贫血诊断和管理中考虑吸烟史的重要性，同时突出了戒烟在减轻不良血液学影响方面的潜在益处。
