Li Qianhui, Lu Hongye, Zhang Mengyuan, Ye Yuting, Chen Qianming, Sun Ping
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
J Zhejiang Univ Sci B. 2025 Jul 4;26(7):657-674. doi: 10.1631/jzus.B2400032.
Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue. Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence, influencing diverse physiological activities, including immune response, inflammation, and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition. However, the impact of these factors on peri-implantitis remains inconclusive. To address this gap, we conducted a comprehensive review to investigate the associations between epigenetic mechanisms and peri-implantitis, specifically focusing on DNA methylation and microRNAs (miRNAs or miRs). We searched for relevant literature on PubMed, Web of Science, Scopus, and Google Scholar with keywords including "epigenetics," "peri-implantitis," "DNA methylation," and "microRNA." DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants. Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective for understanding how local and environmental factors influence the pathogenesis of peri-implantitis. In addition, we assessed the potential application of DNA methylation and miRNAs in the prevention, diagnosis, and treatment of peri-implantitis, aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition. These findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis.
种植体周围疾病的特征是硬组织吸收和软组织炎症。表观遗传学是指DNA序列中未编码的基因表达的改变，影响包括免疫反应、炎症和骨代谢在内的多种生理活动。表观遗传修饰可导致个体间组织特异性基因表达差异，并可能引发或加剧炎症和疾病易感性。然而，这些因素对种植体周围炎的影响仍无定论。为填补这一空白，我们进行了一项全面综述，以研究表观遗传机制与种植体周围炎之间的关联，特别关注DNA甲基化和微小RNA（miRNA或miR）。我们在PubMed、科学网、Scopus和谷歌学术上搜索了相关文献，关键词包括“表观遗传学”、“种植体周围炎”、“DNA甲基化”和“微小RNA”。DNA甲基化和miRNA呈现出一种围绕种植体运作的动态表观遗传机制。与炎症和成骨相关基因的表观遗传修饰为理解局部和环境因素如何影响种植体周围炎的发病机制提供了新的视角。此外，我们评估了DNA甲基化和miRNA在种植体周围炎预防、诊断和治疗中的潜在应用，旨在为未来研究探索潜在治疗靶点和制定更有效的治疗策略奠定基础。这些发现对于理解其他炎症相关口腔疾病如牙周炎的发病机制也具有更广泛的意义。
