Liu Xiangzhi, Zhang Xiangliang, Li Juan, Pan Wenhao, Sun Yiping, Lin Shuanggen, Liu Tao
The State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China.
Beijing Research Institute of Mechanical and Electrical Engineering, Beijing 102202, China.
Bioengineering (Basel). 2025 Jun 24;12(7):686. doi: 10.3390/bioengineering12070686.
The quantitative assessment of Parkinson's disease (PD) is critical for guiding diagnosis, treatment, and rehabilitation. Conventional clinical evaluations-heavily dependent on manual rating scales such as the Unified Parkinson's Disease Rating Scale (UPDRS)-are time-consuming and prone to inter-rater variability. In this study, we propose a fully automated UPDRS gait-scoring framework. Our method combines (a) surface electromyography (EMG) signals and (b) inertial measurement unit (IMU) data into a single deep learning model. Our end-to-end network comprises three specialized branches-a diagnosis head, an evaluation head, and a balance head-whose outputs are integrated via a customized fusion-detection module to emulate the multidimensional assessments performed by clinicians. We validated our system on 21 PD patients and healthy controls performing a simple walking task while wearing a four-channel EMG array on the lower limbs and 2 shank-mounted IMUs. It achieved a mean classification accuracy of 92.8% across UPDRS levels 0-2. This approach requires minimal subject effort and sensor setup, significantly cutting clinician workload associated with traditional UPDRS evaluations while improving objectivity. The results demonstrate the potential of wearable sensor-driven deep learning methods to deliver rapid, reliable PD gait assessment in both clinical and home settings.
帕金森病(PD)的定量评估对于指导诊断、治疗和康复至关重要。传统的临床评估严重依赖于诸如统一帕金森病评定量表(UPDRS)等手动评分量表,既耗时又容易出现评分者间的差异。在本研究中,我们提出了一个全自动的UPDRS步态评分框架。我们的方法将(a)表面肌电图(EMG)信号和(b)惯性测量单元(IMU)数据结合到一个单一的深度学习模型中。我们的端到端网络包括三个专门的分支——一个诊断头、一个评估头和一个平衡头,其输出通过一个定制的融合检测模块进行整合,以模拟临床医生进行的多维评估。我们在21名PD患者和健康对照者身上验证了我们的系统,他们在执行简单步行任务时,下肢佩戴四通道EMG阵列,小腿安装2个IMU。在UPDRS 0 - 2级中,其平均分类准确率达到了92.8%。这种方法所需的受试者努力和传感器设置最少,显著减少了与传统UPDRS评估相关的临床医生工作量,同时提高了客观性。结果表明,可穿戴传感器驱动的深度学习方法在临床和家庭环境中都有提供快速、可靠的PD步态评估的潜力。