Baba Mirela, Maris Mihaela Ioana, Bucur Adina, Jianu Daniela, Moroz Simina Mariana, Stoian Dana, Luca Constantin Tudor, Mozos Ioana
Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Center for Translational Research and Systems Medicine, "Victor Babeş" University of Medicine and Pharmacy, 300173 Timisoara, Romania.
Biomedicines. 2025 Jun 20;13(7):1514. doi: 10.3390/biomedicines13071514.
Hypertension is strongly linked to changes in vascular function and lipid metabolism. This study aimed to examine the relationship between lipid profiles, various metabolic biomarkers, and pulse wave analysis in patients with hypertension. A group of 66 hypertensive patients, aged 64 ± 10 years, participated in pulse wave analysis utilizing an oscillometric device. Multiple lipid serum biomarkers were assessed, such as total cholesterol (TC), triglycerides (TG), and non-HDL cholesterol (non-HDL). Lipid balance index (LBI) was determined by considering TG, LDL, HDL levels, and lipid-lowering medications. Notable correlations were observed for SBP, DBP, and early vascular aging (EVA) with lipid biomarkers. In addition to serum lipids, metabolic syndrome, insulin resistance, and non-alcoholic fatty liver disease (NAFLD) were significantly linked to pulse wave analysis variables. Multiple regression analysis showed that only TC continued to have a significant association with DBP. Total cholesterol, triglycerides, non-HDL cholesterol, and lipid balance index provide information about systolic and diastolic blood pressure, as well as early vascular aging in hypertensive patients. LBI offers valuable vascular insights in hypertensive individuals with cardiovascular risk factors, early vascular aging, insulin resistance, and NAFLD. The connection between metabolic biomarkers and pulse wave measurements in individuals with hypertension offers a comprehensive method for the early identification of vascular injury and could enhance the prediction of major cardiovascular events.
高血压与血管功能和脂质代谢的变化密切相关。本研究旨在探讨高血压患者的血脂谱、各种代谢生物标志物与脉搏波分析之间的关系。一组66名年龄在64±10岁的高血压患者参与了使用示波装置进行的脉搏波分析。评估了多种血脂生物标志物，如总胆固醇（TC）、甘油三酯（TG）和非高密度脂蛋白胆固醇（non-HDL）。通过考虑TG、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）水平和降脂药物来确定脂质平衡指数（LBI）。观察到收缩压（SBP）、舒张压（DBP）和早期血管老化（EVA）与脂质生物标志物之间存在显著相关性。除了血脂外，代谢综合征、胰岛素抵抗和非酒精性脂肪性肝病（NAFLD）也与脉搏波分析变量显著相关。多元回归分析表明，只有TC继续与DBP有显著关联。总胆固醇、甘油三酯、非高密度脂蛋白胆固醇和脂质平衡指数提供了有关高血压患者收缩压和舒张压以及早期血管老化的信息。LBI为具有心血管危险因素、早期血管老化、胰岛素抵抗和NAFLD的高血压个体提供了有价值的血管见解。高血压个体中代谢生物标志物与脉搏波测量之间的联系为早期识别血管损伤提供了一种综合方法，并可增强对主要心血管事件的预测。
