血清脂质谱水平与高血压分级之间的关联：在一家健康体检中心进行的横断面研究

The Association between Serum Lipid Profile Levels and Hypertension Grades: A Cross-Sectional Study at a Health Examination Center.

作者信息

Huang Ling, Liu Zhangyi, Zhang Huayang, Li Dan, Li Zhiyi, Huang Jie, He Jie, Lu Lin, Wen Hu, Yuan Huan, Gu Yinshan, Ye Yunli, Lu Jian, Liao Bin, Li Zhengye, Wu Lin, Liu Jinbo, Li Miaoling

机构信息

Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, School of Nursing, Southwest Medical University, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.

Department of Epidemiology and Biostatistics, School of Public Health, Southwest Medical University, Luzhou, 646000, People's Republic of China.

出版信息

High Blood Press Cardiovasc Prev. 2025 Jan;32(1):87-98. doi: 10.1007/s40292-024-00683-9. Epub 2024 Nov 27.

DOI:10.1007/s40292-024-00683-9

PMID:39602007

Abstract

INTRODUCTION

Hypertension and dyslipidemia are major cardiovascular risk factors that often coexist. Hyperlipidemia is a crucial modifiable risk factor in preventing cardiovascular disease.

AIM

We aimed to explore the relationship between lipid levels and the grading of hypertension in a community-based adult population.

METHODS

A total of 63,091 non-employed individuals were included in this study. Measurements included systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting plasma glucose (FPG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (STB), serum creatinine (SCr), blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Chi-square and t-tests were used to obtain basic population characteristics. Multivariate logistic regression was used to evaluate the association between the prevalence of hypertension and lipid profiles, as well as to identify influencing factors. A P-value < 0.05 was considered statistically significant. Statistical charts were utilized to analyze the relationship between lipid parameters and hypertension grades.

RESULTS

A total of 30,588 men and 32,503 women with an average age of 64.57 ± 12.5 years participated in this study. After adjusting STB and TC, every 1 mmol/L increase in TG and LDL-c was associated with a 6.0% and 6.5% increase in the prevalence of hypertension, respectively. Conversely, for every 1 mmol/L increase in HDL-c, the prevalence of hypertension decreased by 4.1%. Increases in TG and LDL-c levels were observed across all grades of hypertension, while very high HDL-c was significantly associated in grade III hypertension (1.54→1.66 mmol/L). Additionally, age, BMI, FPG, ALT, AST, SCr, and BUN significantly influenced the association between hypertension and lipid levels.

CONCLUSION

Hyperlipidemia and hypertension often coexist in health examination populations. Elevated levels of TG and LDL-C are associated with all grades of hypertension, while extremely high HDL-C level is linked to more severe hypertension.

摘要

引言

高血压和血脂异常是常见的心血管危险因素，常并存。高脂血症是预防心血管疾病的关键可改变危险因素。

目的

我们旨在探讨社区成年人群中血脂水平与高血压分级之间的关系。

方法

本研究共纳入63,091名无业人员。测量指标包括收缩压（SBP）﹑舒张压（DBP）﹑体重指数（BMI）﹑空腹血糖（FPG）﹑丙氨酸氨基转移酶（ALT）﹑天冬氨酸氨基转移酶（AST）﹑总胆红素（STB）﹑血清肌酐（SCr）﹑血尿素氮（BUN）﹑总胆固醇（TC）﹑甘油三酯（TG）﹑低密度脂蛋白胆固醇（LDL-c）和高密度脂蛋白胆固醇（HDL-c）。采用卡方检验和t检验获取基本人群特征。多元逻辑回归用于评估高血压患病率与血脂谱之间的关联，并确定影响因素。P值<0.05被认为具有统计学意义。利用统计图分析血脂参数与高血压分级之间的关系。

结果

本研究共纳入30,588名男性和32,503名女性，平均年龄为64.57±12.5岁。调整STB和TC后，TG和LDL-c每升高1 mmol/L，高血压患病率分别增加6.0%和6.5%。相反，HDL-c每升高1 mmol/L，高血压患病率下降4.1%。在所有高血压分级中均观察到TG和LDL-c水平升高，而极高的HDL-c水平与Ⅲ级高血压显著相关（1.54→1.66 mmol/L）。此外，年龄﹑BMI﹑FPG﹑ALT﹑AST﹑SCr和BUN显著影响高血压与血脂水平之间的关联。