Lozanova Vanina, Teofanova Denitsa, Chakarova Bilyana, Rusanov Krasimir, Pachedjieva Kalina, Tosheva Anita, Zagorcheva Tzvetelina, Zagorchev Lyuben
Faculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov blvd., 1164 Sofia, Bulgaria.
AgroBioInstitute, Agricultural Academy, 8 Dragan Tsankov blvd., 1164 Sofia, Bulgaria.
Antioxidants (Basel). 2025 Jun 20;14(7):761. doi: 10.3390/antiox14070761.
Dodders ( spp.) are prominent parasitic plants widely known and exploited in traditional medicine. They are rich in polyphenolics, which determine their strong antioxidant potential. However, comparatively few of the nearly 200 known species have been characterized for their medicinal potential. In the present study, we aimed to explore the antioxidant potential of four of the most widely distributed species in Bulgaria-, , , and . They differed significantly in polyphenolic content and accordingly differed in their antioxidant properties, although this correlation is not always straightforward, as shown in . Furthermore, we evaluated the host plant species' influence on the polyphenolic content, antioxidant properties, and flavonoid profile of , finding a significant enhancement when the parasite was grown on aromatic plants-rosemary and thyme-compared to a model host-. Seven major flavonoids and phenolic acids-chlorogenic acid, kaempferol-3,7--diglucoside, quercetin-3--galactoside, kaempferol-3--galactoside, quercetin-3--glucoside, astragalin, and isorhamnetin-7-glucoside-were annotated after HPLC-MS analysis and found to be affected by the host species. In conclusion, it was found that extracts from different species differ in their antioxidant potential, which the host plants might further modify.
菟丝子属植物是著名的寄生植物，在传统医学中广为人知且被广泛应用。它们富含多酚类物质，这决定了其强大的抗氧化潜力。然而，在近200种已知的菟丝子属植物中，对其药用潜力进行表征的相对较少。在本研究中，我们旨在探究保加利亚分布最广的四种菟丝子属植物——、、和——的抗氧化潜力。它们在多酚含量上有显著差异，因此抗氧化特性也有所不同，不过如图所示，这种相关性并不总是直接的。此外，我们评估了寄主植物种类对菟丝子属植物多酚含量、抗氧化特性和黄酮类化合物谱的影响，发现与模式寄主相比，当菟丝子寄生在芳香植物迷迭香和百里香上时，其抗氧化特性有显著增强。经过高效液相色谱-质谱分析，鉴定出七种主要的黄酮类化合物和酚酸——绿原酸、山奈酚-3,7-二葡萄糖苷、槲皮素-3-半乳糖苷、山奈酚-3-半乳糖苷、槲皮素-3-葡萄糖苷、紫云英苷和异鼠李素-7-葡萄糖苷——并发现它们受寄主种类的影响。总之，研究发现不同菟丝子属植物的提取物在抗氧化潜力上存在差异，寄主植物可能会进一步改变这种差异。
