Kampke Edgar Hell, Barroso Maria Eduarda Souza, Escouto Leonardo da Silva, Covre Luciana Polaco, Gava Ágata Lages, Campagnaro Bianca Prandi, Kuster Ricardo Machado, Meyrelles Silvana Santos
Graduate Program in Physiological Sciences, Federal University of Espirito Santo, Av. Mal. Campos, 1468, Maruipe, Vitoria 29047-105, ES, Brazil.
Division of Medicine, University College London, London WC1E 6BT, UK.
Antioxidants (Basel). 2025 Jul 13;14(7):856. doi: 10.3390/antiox14070856.
Medicinal plants have been traditionally used for generations, often without scientific validation. (), a plant native to Africa, is commonly employed in folk medicine for treating various ailments, including cancer. However, most studies involving this species are limited to in vitro models, and its systemic effects remain poorly understood. This study aimed to evaluate the impact of latex on renal function in healthy Wistar rats. Animals were divided into two groups: a control group receiving water and a treated group receiving latex (13.47 mg/kg) by gavage for 15 days. Renal function was assessed by measuring glomerular filtration rate (GFR), renal plasma flow (RPF), renal blood flow (RBF), renal vascular resistance (RVR), and mean arterial pressure (MAP). Additionally, oxidative stress markers, reactive oxygen/nitrogen species, and inflammatory activity were analyzed in renal tissue. significantly reduced GFR, RPF, and RBF, while increasing RVR and MAP. Renal tissue exhibited elevated levels of advanced oxidation protein products, myeloperoxidase, nitric oxide, and peroxynitrite/hydroxyl radicals. These findings indicate that latex adversely affects renal hemodynamics and promotes oxidative and inflammatory damage, suggesting potential nephrotoxic effects, even in healthy subjects.
药用植物长期以来被世世代代使用，通常未经科学验证。（某植物名称，原文未给出具体拼写）是一种原产于非洲的植物，在民间医学中常用于治疗各种疾病，包括癌症。然而，大多数涉及该物种的研究仅限于体外模型，其全身效应仍知之甚少。本研究旨在评估（某植物名称）乳胶对健康Wistar大鼠肾功能的影响。动物被分为两组：对照组给予水，治疗组通过灌胃给予乳胶（13.47毫克/千克），持续15天。通过测量肾小球滤过率（GFR）、肾血浆流量（RPF）、肾血流量（RBF）、肾血管阻力（RVR）和平均动脉压（MAP）来评估肾功能。此外，还分析了肾组织中的氧化应激标志物、活性氧/氮物种和炎症活性。（某植物名称）乳胶显著降低了GFR、RPF和RBF，同时增加了RVR和MAP。肾组织中晚期氧化蛋白产物、髓过氧化物酶、一氧化氮和过氧亚硝酸盐/羟基自由基水平升高。这些发现表明，（某植物名称）乳胶对肾血流动力学有不利影响，并促进氧化和炎症损伤，表明即使在健康受试者中也可能存在潜在的肾毒性作用。
