Rosolia Capasso Chiara, Miniato Antonio Luca, Di Filippo Paola, Di Ludovico Armando, Di Pillo Sabrina, Chiarelli Francesco, Sferrazza Papa Giuseppe Francesco, Attanasi Marina
Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n°5, 66100 Chieti, Italy.
Department of Neurorehabilitation Sciences, Casa di Cura Igea, 20144 Milan, Italy.
Children (Basel). 2025 Jun 23;12(7):831. doi: 10.3390/children12070831.
Cystic fibrosis (CF) is a chronic genetic disease marked by progressive lung function decline and increased respiratory infections. Emerging evidence supports the role of physical exercise in improving lung function, aerobic capacity, and quality of life in pediatric CF patients.
We reviewed randomized clinical trials and observational studies from the last ten years, sourced from PubMed and Google Scholar. Included studies involved children and adolescents (0-18 years) with CF and assessed physical exercise as a primary intervention to improve lung function, aerobic fitness, quality of life, or hospitalization rates.
Aerobic training, particularly when combined with strength training, improves cardiorespiratory fitness and muscle strength without compromising nutritional status. High-Intensity Interval Training and Inspiratory Muscle Training show potential but need further validation. Supervised, personalized exercise programs are key to promoting adherence and optimizing outcomes.
Exercise-based interventions in pediatric CF should evolve toward personalized, technology-enhanced, and sustainable models. Integrating wearable devices, adapting programs to individual needs, and leveraging early parental involvement may enhance engagement and outcomes, especially in the era of CFTR modulator therapies.
囊性纤维化（CF）是一种慢性遗传疾病，其特征为肺功能逐渐下降以及呼吸道感染增加。新出现的证据支持体育锻炼在改善儿科CF患者肺功能、有氧能力和生活质量方面的作用。
我们回顾了过去十年来自PubMed和谷歌学术搜索的随机临床试验和观察性研究。纳入的研究涉及患有CF的儿童和青少年（0至18岁），并将体育锻炼作为改善肺功能、有氧适能、生活质量或住院率的主要干预措施进行评估。
有氧训练，特别是与力量训练相结合时，可改善心肺适能和肌肉力量，且不影响营养状况。高强度间歇训练和吸气肌训练显示出潜力，但需要进一步验证。有监督的个性化运动计划是促进依从性和优化结果的关键。
儿科CF中基于运动的干预措施应朝着个性化、技术增强和可持续的模式发展。整合可穿戴设备、根据个体需求调整计划以及利用父母早期参与可能会提高参与度和改善结果，尤其是在CFTR调节剂治疗的时代。
