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[疑似心肌结节病的心肌活检]

[Myocardial biopsy in suspected myocardial sarcoidosis].

作者信息

Schaedel H, Haenselt V, Kirsten D, Eger H

出版信息

Z Gesamte Inn Med. 1985 Sep 15;40(18):555-6.

PMID:4072308
Abstract

24 patients with pulmonary sarcoidosis stage I or II, who above all on account of changes of the ECG roused the suspicion of the presence of a sarcoidosis of the myocardium, finally underwent an invasive examination with laevocardiography, coronarography and biopsy of the endomyocardium. While the unaimed taking of tissue from the left ventricle did not result light-microscopically in a reference to granulomas or other inflammatory changes, the biopsy in a female patient, on purpose taken from a hypokinetic area of the left ventricle, showed epitheloid-cellular granulomas with giant-cells. Evaluating these results and reports in literatur, we came to the conclusion that findings typical for sarcoidosis are promising success only when taken from cardiographically suspicious areas of the myocardium.

摘要

24例I期或II期肺结节病患者,主要因心电图改变而怀疑存在心肌结节病,最终接受了左心导管检查、冠状动脉造影和心内膜活检等侵入性检查。虽然从左心室随机取材在光学显微镜下未发现肉芽肿或其他炎症改变,但在一名女性患者中,特意从左心室运动减弱区域取材的活检显示有上皮样细胞肉芽肿和巨细胞。综合这些结果以及文献报道,我们得出结论,只有从心肌心电图可疑区域取材,结节病的典型表现才有望获得成功诊断。

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1
[Myocardial biopsy in suspected myocardial sarcoidosis].[疑似心肌结节病的心肌活检]
Z Gesamte Inn Med. 1985 Sep 15;40(18):555-6.
2
[Biopsy confirmation of clinically suspected heart sarcoidosis].
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3
[The value of endomyocardial biopsy in verifying the diagnosis of sarcoidosis of the heart].
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[Myocardial sarcoidosis--pathological studies on 7 autopsy cases with particular reference to histological variations].[心肌结节病——7例尸检病例的病理研究,特别提及组织学变异]
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Prospective study of cardiac sarcoid mimicking arrhythmogenic right ventricular dysplasia.模仿致心律失常性右心室发育不良的心脏结节病的前瞻性研究。
J Cardiovasc Electrophysiol. 2009 May;20(5):473-6. doi: 10.1111/j.1540-8167.2008.01351.x. Epub 2008 Nov 11.
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A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy.结节病的心肌内膜活检结果呈阳性与最初病因不明的心肌病患者的预后不良相关。
Am Heart J. 2005 Sep;150(3):459-63. doi: 10.1016/j.ahj.2004.10.006.
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Giant cell myocarditis: an entity distinct from sarcoidosis characterized by multiphasic myocyte destruction by cytotoxic T cells and histiocytic giant cells.巨细胞性心肌炎:一种与结节病不同的疾病实体,其特征为细胞毒性T细胞和组织细胞性巨细胞对心肌细胞进行多阶段破坏。
Mod Pathol. 1996 Dec;9(12):1126-34.
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[A case of latent cardiac sarcoidosis in reference to differential diagnosis from giant cell myocarditis].[一例潜在性心脏结节病的鉴别诊断——与巨细胞性心肌炎的对比]
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[Case of cardiac sarcoidosis confirmed by myocardial biopsy].[经心肌活检确诊的心脏结节病病例]
Nihon Kyobu Shikkan Gakkai Zasshi. 1983 Mar;21(3):270-5.