Alansari Amani N, Zaazouee Mohamed Sayed, Najar Safaa, Elshanbary Alaa Ahmed
Department of Pediatric Surgery, Hamad Medical Corporation, Doha 3050, Qatar.
Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Children (Basel). 2025 Jul 7;12(7):891. doi: 10.3390/children12070891.
Thyroid disorders are significant endocrine conditions in pediatric populations, sometimes requiring surgical intervention. While surgical outcomes are well-documented, the broader impact on quality of life (QoL) remains insufficiently synthesized. This systematic review aimed to evaluate the effects of thyroid surgery on QoL in pediatric patients, focusing on physical, emotional, and social dimensions. Following the PRISMA guidelines, we searched PubMed, EMBASE, and SCOPUS from inception to January 2025. Studies reporting health-related QoL outcomes in pediatric patients undergoing thyroid surgery were included. Quality assessment was conducted using the Newcastle-Ottawa Scale. Data synthesis focused on emotional and psychological outcomes, social functioning, physical health, and surgical-approach-specific effects. Five studies (ranging from 37 to 92 participants) met the inclusion criteria. Unilateral thyroidectomy was associated with better QoL outcomes compared to bilateral procedures, particularly in emotional and physical domains. Post-surgical anxiety significantly improved. However, male survivors reported higher levels of depression and reduced motivation. Employment status emerged as a significant factor influencing physical functioning scores. Thyroid cancer patients demonstrated better social functioning than peers with other cancers, yet they lagged behind healthy controls. Long-term follow-up highlighted ongoing challenges in physical functioning and fatigue. Thyroid surgery impacts multiple dimensions of QoL in pediatric patients, with variations depending on surgical approach and patient characteristics. These findings underscore the need for comprehensive post-operative care, including routine QoL assessments and tailored psychological support. Future research should aim to standardize assessment timing and develop targeted interventions for high-risk groups.
甲状腺疾病是儿科人群中重要的内分泌疾病，有时需要手术干预。虽然手术结果已有充分记录，但对生活质量（QoL）的更广泛影响仍未得到充分综合分析。本系统评价旨在评估甲状腺手术对儿科患者生活质量的影响，重点关注身体、情感和社会维度。按照PRISMA指南，我们检索了从创刊到2025年1月的PubMed、EMBASE和SCOPUS数据库。纳入报告接受甲状腺手术的儿科患者健康相关生活质量结果的研究。使用纽卡斯尔-渥太华量表进行质量评估。数据综合分析聚焦于情感和心理结果、社会功能、身体健康以及特定手术方式的影响。五项研究（参与者从37人到92人不等）符合纳入标准。与双侧手术相比，单侧甲状腺切除术与更好的生活质量结果相关，尤其是在情感和身体领域。术后焦虑显著改善。然而，男性幸存者报告的抑郁水平较高且动力下降。就业状况成为影响身体功能评分的一个重要因素。甲状腺癌患者的社会功能比其他癌症患者的同龄人更好，但仍落后于健康对照组。长期随访突出了身体功能和疲劳方面持续存在的挑战。甲状腺手术会影响儿科患者生活质量的多个维度，因手术方式和患者特征而异。这些发现强调了术后综合护理的必要性，包括常规生活质量评估和量身定制的心理支持。未来的研究应旨在规范评估时间，并为高危人群制定有针对性的干预措施。
