Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada.
School of Communication Sciences and Disorders, McGill University, Montreal, QC H3A 0G4, Canada.
Curr Oncol. 2022 Jun 21;29(7):4386-4422. doi: 10.3390/curroncol29070350.
Health-related quality of life (HrQoL) is a major concern for patients with differentiated thyroid carcinoma (DTC). We aimed to systematically review the literature comparing HrQol following total thyroidectomy (TT) and hemithyroidectomy (HT) in DTC patients. A systematic review of publications indexed in Medline, Embase, and EBM reviews-Cochrane Central Register of Controlled Trials, which evaluated HrQoL following thyroid surgery for DTC, was conducted. Of 2507 identified records, 25 fulfilled the inclusion criteria. Our results suggest that patients undergoing TT may suffer more impairment in physical and social HrQoL than patients undergoing HT. Psychological-related HrQoL and long-term global HrQoL are, however, equivalent in both groups, which highlights the multidimensional nature of HrQoL and the importance of a multitude of factors aside from treatment modalities and related morbidities, such as the experience of receiving a cancer diagnosis, the fear of cancer recurrence, and other psychosocial factors. Addressing postoperative HrQoL when discussing therapeutic options with patients is an integral part of patient-centered care and informed shared decision-making, and should be approached in a holistic manner, accounting for its physical, psychological, and social aspects. This review supplies evidence regarding HrQoL following thyroid surgery, which can be employed in such decisions.
健康相关生活质量（HrQoL）是分化型甲状腺癌（DTC）患者关注的主要问题。我们旨在系统地回顾比较 DTC 患者行甲状腺全切除术（TT）和甲状腺次全切除术（HT）后生活质量的文献。对在 Medline、Embase 和 EBM Reviews-Cochrane 对照试验中心注册索引的出版物进行了系统回顾，这些出版物评估了 DTC 甲状腺手术后的 HrQoL。在 2507 条已识别的记录中，有 25 条符合纳入标准。我们的结果表明，与接受 HT 的患者相比，接受 TT 的患者可能在身体和社会 HrQoL 方面受到更大的损害。然而，两组之间心理相关的 HrQoL 和长期总体 HrQoL 是等效的，这突出了 HrQoL 的多维性质以及除了治疗方式和相关发病率以外的许多因素的重要性，例如接受癌症诊断的经历、对癌症复发的恐惧以及其他社会心理因素。在与患者讨论治疗方案时，关注术后 HrQoL 是患者为中心的护理和知情共享决策的一个组成部分，应该采用整体的方法，考虑到其身体、心理和社会方面。本综述提供了有关甲状腺手术后 HrQoL 的证据，可用于此类决策。
