Quattrone Alda, Beqiraj Doriana, Fehri Nour Elhouda, Belabbas Rafik, Vigo Daniele, Menchetti Laura, Barbato Olimpia, Failla Sebastiana, Faustini Massimo, Ghoneim Shereen Salama, Jemmali Bayrem, Mattioli Simona, Contò Michela, Munga Albana, Dal Bosco Alessandro, Ben Salem Imène, Ozuni Enkeleda, Or Mehmet Erman, Andoni Egon, Gualazzi Fabio, Castrica Marta, Brecchia Gabriele, Curone Giulio
Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
Faculty of Veterinary Medicine, Agricultural University of Tirana, Kodër Kamëz, 1029 Tirana, Albania.
Animals (Basel). 2025 Jul 15;15(14):2085. doi: 10.3390/ani15142085.
This study evaluated the effects of dietary supplementation with omega-3 polyunsaturated fatty acids from extruded linseed, alone and combined with algae extract, on growth performance and metabolic status in fattening rabbits. Sixty New Zealand White rabbits were assigned to three groups, as follows: control (CNT), L (5% linseed), and LPP (3.5% linseed + 0.2% algae extract) from weaning (37 days) to slaughter (85 days). Productive performance was assessed through body weight (BW), average daily gain (ADG), feed conversion ratio (FCR), and feed intake (FI). Blood was sampled at weaning, 60 days, and slaughter and analyzed for insulin, leptin, cortisol, thyroid hormones (T3, T4), glucose, and non-esterified fatty acids (NEFAs). The L group showed significantly higher ADG (41.0 ± 1 g/d) and improved FCR (4.1 ± 0.2) compared to LPP (ADG: 37 ± 1 g/d, FCR: 4.6 ± 0.2; = 0.001). No differences were observed in final BW or FI among groups ( < 0.001). Insulin peaked at 60 days across all groups ( < 0.001), with the LPP group showing the lowest levels (9.8 ± 0.9 µUI/mL; = 0.043). T3 and T4 increased significantly with age ( < 0.001), and the T3/T4 ratio varied by diet and time ( = 0.005). Cortisol rose only at slaughter ( < 0.001) and negatively correlated with insulin and thyroid hormones. The results suggest that omega-3-rich nutraceuticals can enhance growth performance without disrupting metabolic balance and may modulate specific hormonal responses due to their bioactive compounds.
本研究评估了从挤压亚麻籽中提取的ω-3多不饱和脂肪酸单独以及与藻类提取物联合添加到日粮中，对育肥兔生长性能和代谢状况的影响。将60只新西兰白兔分为三组，如下：对照组（CNT）、L组（5%亚麻籽）和LPP组（3.5%亚麻籽 + 0.2%藻类提取物），从断奶（37日龄）至屠宰（85日龄）。通过体重（BW）、平均日增重（ADG）、饲料转化率（FCR）和采食量（FI）评估生产性能。在断奶、60日龄和屠宰时采集血液，分析胰岛素、瘦素、皮质醇、甲状腺激素（T3、T4）、葡萄糖和非酯化脂肪酸（NEFA）。与LPP组（ADG：37±1 g/d，FCR：4.6±0.2；P = 0.001）相比，L组的ADG显著更高（41.0±1 g/d），FCR有所改善。各组之间在最终体重或采食量方面未观察到差异（P<0.001）。所有组的胰岛素在60日龄时达到峰值（P<0.001），LPP组的胰岛素水平最低（9.8±0.9 µUI/mL；P = 0.043）。T3和T4随年龄显著增加（P<0.001），T3/T4比值因日粮和时间而异（P = 0.005）。皮质醇仅在屠宰时升高（P<0.001），且与胰岛素和甲状腺激素呈负相关。结果表明，富含ω-3的营养保健品可增强生长性能而不扰乱代谢平衡，并且可能因其生物活性化合物而调节特定的激素反应。
