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极早早产儿先天性败血症:病例报告与文献综述

Congenital Sepsis in an Extremely Preterm Baby: Case Report and Literature Review.

作者信息

Cossovel Francesca, Nider Silvia, Bua Jenny, Ghirigato Elena, Piccoli Monica, Manzoni Paolo, Travan Laura

机构信息

Department of Neonatology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.

Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.

出版信息

Antibiotics (Basel). 2025 Jun 30;14(7):666. doi: 10.3390/antibiotics14070666.

Abstract

A preterm neonate born at 24 + 5 weeks gestation developed congenital sepsis, diagnosed via placental culture, axillary swab, and elevated beta-glucan levels. Although initial blood cultures were negative, continuous HeRo monitoring played a crucial role in the early detection of clinical deterioration, prompting timely antifungal therapy with amphotericin B followed by micafungin. This proactive approach, combining prompt diagnosis, HeRo surveillance, and tailored treatment, ensured a favorable outcome. Our case underscores the value of HeRo monitoring as an early warning tool in managing neonatal fungal infections.

摘要

一名孕24⁺⁵周出生的早产儿发生先天性败血症,通过胎盘培养、腋窝拭子和β-葡聚糖水平升高得以诊断。尽管初始血培养结果为阴性,但连续的HeRo监测在临床病情恶化的早期检测中发挥了关键作用,促使及时使用两性霉素B进行抗真菌治疗,随后使用米卡芬净。这种积极主动的方法,结合及时诊断、HeRo监测和个性化治疗,确保了良好的结果。我们的病例强调了HeRo监测作为管理新生儿真菌感染的早期预警工具的价值。

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