Giammarino Andrea, Verdolini Laura, Simonetti Giovanna, Angiolella Letizia
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00100 Rome, Italy.
Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Antibiotics (Basel). 2025 Jul 17;14(7):718. doi: 10.3390/antibiotics14070718.
: There is an increasing incidence of fungal infections in conjunction with the rise in resistance to medical treatment. Antimicrobial resistance is frequently associated with virulence factors such as adherence and the capacity of biofilm formation, which facilitates the evasion of the host immune response and resistance to drug action. Novel therapeutic strategies have been developed to overcome antimicrobial resistance, including the use of different type of nanomaterials: metallic (Au, Ag, FeO and ZnO), organic (e.g., chitosan, liposomes and lactic acid) or carbon-based (e.g., quantum dots, nanotubes and graphene) materials. The objective of this study was to evaluate the action of nanoparticles of different synthesis and with different coatings on fungi of medical interest. : Literature research was conducted using PubMed and Google Scholar databases, and the following terms were employed in articles published up to June 2025: 'nanoparticles' in combination with 'fungal biofilm', ' biofilm', ' biofilm', ' biofilm', ' biofilm' and 'dermatophytes biofilm'. : The utilization of nanoparticles was found to exert a substantial impact on the reduction in fungal biofilm, despite the presence of substantial variability in minimum inhibitory concentration (MIC) values attributable to variations in nanoparticle type and the presence of capping agents. It was observed that the MIC values were lower for metallic nanoparticles, particularly silver, and for those synthesized with polylactic acid compared to the others. : Despite the limited availability of data concerning the stability and biocompatibility of nanoparticles employed in the treatment of fungal biofilms, it can be posited that these results constitute a significant initial step.
随着医疗耐药性的增加,真菌感染的发病率也在上升。抗菌耐药性通常与毒力因子有关,如黏附性和生物膜形成能力,这有助于逃避宿主免疫反应和抵抗药物作用。为了克服抗菌耐药性,人们开发了新的治疗策略,包括使用不同类型的纳米材料:金属(金、银、氧化亚铁和氧化锌)、有机(如壳聚糖、脂质体和乳酸)或碳基(如量子点、纳米管和石墨烯)材料。本研究的目的是评估不同合成方法和不同涂层的纳米颗粒对医学相关真菌的作用。:使用PubMed和谷歌学术数据库进行文献研究,在截至2025年6月发表的文章中使用了以下术语:“纳米颗粒”与“真菌生物膜”、“生物膜”、“生物膜”、“生物膜”、“生物膜”和“皮肤癣菌生物膜”组合。:尽管由于纳米颗粒类型和封端剂的存在,最小抑菌浓度(MIC)值存在很大差异,但发现纳米颗粒的使用对减少真菌生物膜有重大影响。观察到,与其他纳米颗粒相比,金属纳米颗粒,特别是银纳米颗粒以及用聚乳酸合成的纳米颗粒的MIC值较低。:尽管关于用于治疗真菌生物膜的纳米颗粒的稳定性和生物相容性的数据有限,但可以认为这些结果构成了重要的初步步骤。
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