Liu Fujun, Ran Qibo, Li Zhongyu, Chen Jing
State Key Laboratory of Biotherapy Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
J Clin Med. 2025 Jul 10;14(14):4908. doi: 10.3390/jcm14144908.
: The red blood cell distribution width-to-albumin ratio (RAR) serves as an indicator of systemic inflammation and nutritional status. The precise relationship between the RAR and Parkinson's disease (PD) prevalence remains unclear. : This study examines the association between the RAR and PD in U.S. adults aged over 40, utilizing data from the NHANES (2003-2018). Logistic regression, subgroup analyses, and restricted cubic spline (RCS) models were utilized to evaluate the relationship between the RAR and PD prevalence. Of 22,617 participants, 287 had PD. The mean RAR was higher in PD (3.32 ± 0.04) vs. that in non-PD (3.16 ± 0.01; < 0.0001). Each unit increase in the RAR was linked to a 47% rise in the PD odds (OR = 1.47; 95% CI, 1.16-1.86; < 0.05). The prevalence of PD in the highest quintile (Q3) was 1.921 times higher than that in the lowest quintile (Q1) (OR = 1.921; 95% CI, 1.128-3.270). Higher RAR values were significantly associated with increased odds of PD prevalence (-values for trend < 0.05). The RCS analysis indicated a nonlinear association between the RAR and PD prevalence odds ( = 0.0423), with RARs ≥ 3.12 associated with increased odds of PD prevalence. Subgroup analyses and interaction tests validated the robustness of the findings regarding the association. : This study found a positive nonlinear relationship between the RAR and PD prevalence. The odds of PD prevalence increased notably when the RAR exceeded approximately 3.12, and they continued to rise with increasing RARs. Due to the cross-sectional design, causality cannot be confirmed. Further research is needed to explore the mechanisms linking the RAR and PD.
红细胞分布宽度与白蛋白比值（RAR）是全身炎症和营养状况的一个指标。RAR与帕金森病（PD）患病率之间的确切关系仍不清楚。 本研究利用美国国家健康与营养检查调查（NHANES，2003 - 2018年）的数据，调查了40岁以上美国成年人中RAR与PD之间的关联。采用逻辑回归、亚组分析和受限立方样条（RCS）模型来评估RAR与PD患病率之间的关系。在22617名参与者中，287人患有PD。PD患者的平均RAR（3.32±0.04）高于非PD患者（3.16±0.01；P<0.0001）。RAR每增加一个单位，PD患病几率就会增加47%（OR = 1.47；95%CI，1.16 - 1.86；P<0.05）。最高五分位数（Q3）的PD患病率比最低五分位数（Q1）高1.921倍（OR = 1.921；95%CI，1.128 - 3.270）。较高的RAR值与PD患病率增加的几率显著相关（趋势P值<0.05）。RCS分析表明RAR与PD患病率几率之间存在非线性关联（P = 0.0423），RAR≥3.12与PD患病率增加的几率相关。亚组分析和交互检验验证了关于该关联研究结果的稳健性。 本研究发现RAR与PD患病率之间存在正非线性关系。当RAR超过约3.12时，PD患病率的几率显著增加，并且随着RAR的增加继续上升。由于采用横断面设计，无法确定因果关系。需要进一步研究以探索RAR与PD之间的关联机制。
