Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China.
Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Center for Drug Research and Development of Guangdong Pharmaceutical University, Guangzhou 510006, China.
Molecules. 2022 Nov 3;27(21):7520. doi: 10.3390/molecules27217520.
is a genus of commensal and lipid-dependent yeasts in human skin which also have a pathogenic lifestyle associated with several common skin disorders such as atopic dermatitis and eczema. Symptoms include red, itchy, and inflamed skin. We studied the growth characteristics and biochemical analyses of which showed that the protein contents were greater in extracts taken at 24 h. These were then used to infect C57BL/6 mice, resulting in skin rupture. Polygalaxanthone III (POL), a more effective anti-inflammatory ingredient in , was applied externally to the ulceration and successfully healed the wounds quickly. POL could not inhibit activity as tested by the inhibition zone test, but affected the formation of lipid droplets in HaCaT cells. The wound-healing molecular mechanisms may be involved in the STAT3 pathway according to the Western blot results of skin tissues. 's role in skin health is far from certain, and there is no clear solution, so understanding the development of -associated skin diseases in general and seeking solutions are very important.
马拉色菌是一种寄生于人类皮肤的共生和脂质依赖性酵母，也具有与多种常见皮肤疾病相关的致病性生活方式，如特应性皮炎和湿疹。其症状包括皮肤发红、瘙痒和发炎。我们研究了马拉色菌的生长特性和生化分析，结果表明在 24 小时提取的提取物中蛋白质含量更高。然后，我们将这些提取物用于感染 C57BL/6 小鼠，导致皮肤破裂。马拉色菌中更有效的抗炎成分 Polygalaxanthone III（POL）被用于溃疡的外部治疗，成功地迅速治愈了伤口。通过抑菌圈试验表明 POL 不能抑制马拉色菌的活性，但会影响 HaCaT 细胞中脂滴的形成。根据皮肤组织的 Western blot 结果，伤口愈合的分子机制可能涉及 STAT3 途径。马拉色菌在皮肤健康中的作用还远未确定，也没有明确的解决方案，因此了解与马拉色菌相关的皮肤疾病的发展并寻求解决方案非常重要。
