肠道微生物群对耳鸣的因果效应：一项孟德尔随机化研究。

Causal Effects of Gut Microbiome on Tinnitus: A Mendelian Randomization Study.

作者信息

Zeng Qiang, Xie Wei, Dong Huaqian, Liu Xing, Shao Shuai, Chen Li, Zhang Wenwen

机构信息

School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, People's Republic of China.

Department of Nursing, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, People's Republic of China.

出版信息

J Multidiscip Healthc. 2025 Jul 22;18:4159-4172. doi: 10.2147/JMDH.S525502. eCollection 2025.

DOI:10.2147/JMDH.S525502

PMID:40727005

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301115/

Abstract

BACKGROUND

Previous studies have identified a clinical association between gut microbiota (GM) and tinnitus; however, the potential causal relationship remains unclear. Therefore, we conducted a Mendelian randomization(MR) study to evaluate the potential causal effects of 412 gut microbiome features on tinnitus risk.

METHODS

In the study, we used pooled data from a genome-wide association study(GWAS) of gut microbes from a Dutch population. Summary statistics of tinnitus were drawn from the FinnGen R10 database. Inverse variance weighted, weighted median and MR-Egger were used to evaluate the potential causal link between GM and tinnitus.

RESULTS

The MR analysis revealed a negative association between the abundance of and the risk of tinnitus (OR = 0.84, 95% CI: 0.74-0.94, = 0.003), suggesting a potential protective role. Conversely, positive associations were observed for (OR = 1.11, 95% CI: 1.01-1.22, = 0.032), , and , all linked to increased tinnitus risk.

CONCLUSION

Our findings suggest potential causal effects of specific gut microbial taxa and pathways on tinnitus, highlighting promising targets for prevention and treatment. However, further research is needed to validate these associations and clarify underlying mechanisms.

摘要

背景

先前的研究已确定肠道微生物群（GM）与耳鸣之间存在临床关联；然而，潜在的因果关系仍不清楚。因此，我们进行了一项孟德尔随机化（MR）研究，以评估412种肠道微生物组特征对耳鸣风险的潜在因果效应。

方法

在本研究中，我们使用了来自荷兰人群肠道微生物全基因组关联研究（GWAS）的汇总数据。耳鸣的汇总统计数据来自芬兰基因R10数据库。采用逆方差加权、加权中位数和MR-Egger方法评估GM与耳鸣之间的潜在因果联系。

结果

MR分析显示，[具体微生物名称1]的丰度与耳鸣风险呈负相关（OR = 0.84，95% CI：0.74 - 0.94，P = 0.003），表明其可能具有保护作用。相反，观察到[具体微生物名称2]（OR = 1.11，95% CI：1.01 - 1.22，P = 0.032）、[具体微生物名称3]和[具体微生物名称4]呈正相关，均与耳鸣风险增加有关。