Molecular and Mitochondrial Medicine Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo No. 2, 46001 Valencia, Spain.
Translational Research Center San Alberto Magno CITSAM, Catholic University of Valencia San Vicente Mártir, C/Quevedo No. 2, 46001 Valencia, Spain.
Int J Mol Sci. 2024 Oct 10;25(20):10879. doi: 10.3390/ijms252010879.
Inflammatory bowel disease is a chronic condition characterized by recurrent intestinal inflammation. Its etiopathogenesis is driven by a series of events that disrupt the mucosal barrier, alter the healthy balance of intestinal microbiota, and abnormally stimulate intestinal immune responses. Therefore, numerous studies suggest the use of short-chain fatty acids and their immunomodulatory effects as a therapeutic approach in this disease. The objective of this systematic review was to synthesize previous evidence on the relevance and therapeutic use of short-chain fatty acids, particularly butyrate, in the immune regulation of inflammatory bowel disease. This systematic review of articles linking inflammatory bowel disease with short-chain fatty acids was conducted according to the PRISMA-2020 guidelines. The Medline and the Web of Science databases were searched in August 2024. The risk of bias was assessed using the Joanna Briggs Institute checklists. A total of 1460 articles were reviewed, of which, 29 met the inclusion criteria. Short-chain fatty acids, particularly butyrate, play a critical role in the regulation of intestinal inflammation and can be used as a strategy to increase the levels of short-chain fatty acid-producing bacteria for use in therapeutic approaches.
炎症性肠病是一种慢性疾病，其特征是反复发作的肠道炎症。其发病机制是一系列破坏黏膜屏障、改变肠道微生物群健康平衡、异常刺激肠道免疫反应的事件驱动的。因此，许多研究表明，短链脂肪酸及其免疫调节作用可作为该疾病的一种治疗方法。本系统评价的目的是综合以前关于短链脂肪酸（特别是丁酸盐）在炎症性肠病免疫调节中的相关性和治疗用途的证据。根据 PRISMA-2020 指南对将炎症性肠病与短链脂肪酸联系起来的文章进行了系统评价。于 2024 年 8 月在 Medline 和 Web of Science 数据库中进行了检索。使用 Joanna Briggs 研究所清单评估了偏倚风险。共审查了 1460 篇文章，其中 29 篇符合纳入标准。短链脂肪酸，特别是丁酸盐，在调节肠道炎症中起着关键作用，可以用作增加产生短链脂肪酸的细菌水平的策略，用于治疗方法。
