Sexton Gerard P, Griffin Katherine, Lockhart Rachel, Skinner Liam
Department of Otolaryngology, Head & Neck Surgery, University Hospital Waterford, Waterford X91ER8E, Ireland.
Department of Histopathology, Tallaght University Hospital, Waterford D24NR0A, Ireland.
J Surg Case Rep. 2025 Jul 28;2025(7):rjaf512. doi: 10.1093/jscr/rjaf512. eCollection 2025 Jul.
Plasma cell mucositis (PCM) is a rare inflammatory condition of the upper aerodigestive tract with a heterogeneous clinical course. Predominately seen in the oral cavity, laryngeal involvement and the requirement for tracheostomy have been rarely described. We describe the case of a man diagnosed with airway-threatening PCM isolated to the larynx requiring a tracheostomy. He responded to oral glucocorticoids and was decannulated only to present 3 years later with severe laryngeal stenosis requiring repeat tracheostomy insertion. Medical management in the form of immunosuppression is the mainstay of treatment for plasma cell mucositis. Surgical management is necessary in a significant proportion of cases with laryngeal involvement.
浆细胞性黏膜炎(PCM)是上消化道气道的一种罕见炎症性疾病,临床病程各异。主要见于口腔,喉部受累及气管切开需求的相关描述很少。我们报告一例诊断为孤立于喉部的威胁气道的PCM患者,该患者需要气管切开。他对口服糖皮质激素有反应,拔管后3年却因严重喉狭窄需要再次插入气管切开管。免疫抑制形式的药物治疗是浆细胞性黏膜炎的主要治疗方法。在相当一部分喉部受累的病例中,手术治疗是必要的。