Huang Jianling, Zhang Dengke, Zhu Chenghua, Chen Shijun, Wang Yueyue, Han Kexing, Ci Shusheng, Lv Yunxiang
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical University Bengbu Anhui 233000 China
Nanjing Pukou Hospital of TCM, Pukou Hospital of Chinese Medicine Affiliated to China Pharmaceutical University Nanjing 210000 China
RSC Adv. 2025 Jul 28;15(33):26728-26738. doi: 10.1039/d5ra01352f. eCollection 2025 Jul 25.
Bacterial infections pose a serious threat to human health, and antibiotic resistance has greatly hindered their clinical application. Therefore, new antibacterial compounds or alternative approaches are urgently needed. In recent years, nanoscience and nanotechnology have developed a number of antimicrobial nanoparticles that can be used as new tools to fight deadly bacterial infections. Graphene-based nanomaterials (GBNs), such as graphene oxide (GO) and reduced graphene oxide (rGO), have shown great potential in the treatment and management of bacteria-induced infectious diseases due to their outstanding biological properties. This review provides a comprehensive understanding of the antibacterial application of GBNs summarizing their classifications, structural features, antibacterial mechanisms and concrete applications in the treatment of multidrug resistant (MDR) bacterial infection. We highlight the advances in development of GBNs and GBNs-based treatment strategies, including photothermal therapy (PTT), photodynamic therapy (PDT) and multiple combination therapies. In addition, we conclude and discuss the challenges and problems in using these nanomaterials. Collectively, we believe that GBNs have the potential to be an effective clinical treatment for MDR bacterial infections.
细菌感染对人类健康构成严重威胁，而抗生素耐药性极大地阻碍了其临床应用。因此，迫切需要新的抗菌化合物或替代方法。近年来，纳米科学和纳米技术开发了多种抗菌纳米颗粒，可作为对抗致命细菌感染的新工具。基于石墨烯的纳米材料（GBNs），如氧化石墨烯（GO）和还原氧化石墨烯（rGO），由于其出色的生物学特性，在细菌感染性疾病的治疗和管理中显示出巨大潜力。本综述全面介绍了GBNs的抗菌应用，总结了它们的分类、结构特征、抗菌机制以及在治疗多重耐药（MDR）细菌感染中的具体应用。我们重点介绍了GBNs及其基于GBNs的治疗策略的发展进展，包括光热疗法（PTT）、光动力疗法（PDT）和多种联合疗法。此外，我们总结并讨论了使用这些纳米材料时面临的挑战和问题。总体而言，我们认为GBNs有潜力成为治疗MDR细菌感染的有效临床方法。
