Antonini Marina, Aguzzi Cristina, Fanelli Alessandro, Frassineti Andrea, Zeppa Laura, Morelli Maria Beatrice, Pastore Gabriella, Nabissi Massimo, Luongo Margherita
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Reports (MDPI). 2023 May 5;6(2):22. doi: 10.3390/reports6020022.
Glioblastoma is the most aggressive malignant tumor overall and remains an incurable neoplasm with a median survival of 15 months. Since 2005, the gold standard treatment for glioblastoma has remained unchanged, and it is a common goal of the scientific community to work towards a better prognosis and improved survival for glioblastoma patients. Herein, we report a case of glioblastoma multiforme in a patient with a poor prognosis who, following partial removal of the neoplasm, refused conventional therapy consisting of a combination of radiotherapy and temozolomide-based chemotherapy due to personal serious side effects. The patient started an unconventional therapeutic path by alternating periods of oxygen-ozone therapy with concomitant administration of legal medical cannabis products (Bedrocan and Bedrolite) and melatonin. This approach resulted in a complete and durable remission of the disease and long survival. Indeed, the patient is still alive. The exceptional result obtained here encourages us to share and carefully investigate this unconventional treatment as a possible future direction in the management of glioblastoma.
胶质母细胞瘤是总体上最具侵袭性的恶性肿瘤，仍然是一种无法治愈的肿瘤，中位生存期为15个月。自2005年以来，胶质母细胞瘤的金标准治疗方法一直未变，改善胶质母细胞瘤患者的预后和提高生存率是科学界的共同目标。在此，我们报告一例预后不良的多形性胶质母细胞瘤患者，该患者在肿瘤部分切除后，因个人严重副作用拒绝了由放疗和替莫唑胺化疗组成的传统治疗。该患者开始了一条非传统的治疗路径，交替进行臭氧治疗，并同时使用合法的医用大麻产品（Bedrocan和Bedrolite）以及褪黑素。这种方法导致疾病完全持久缓解并长期存活。事实上，该患者仍然活着。此处获得的特殊结果鼓励我们分享并仔细研究这种非传统治疗方法，将其作为胶质母细胞瘤治疗未来可能的方向。
