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应用培养的自体软骨细胞优化膝关节剥脱性骨软骨炎的胶原支架:1例报告

Optimization of Collagen Scaffold with Cultured Autologous Chondrocytes for Osteochondritis Dissecans of the Knee: A Case Report.

作者信息

Valladares Nicolas, Jacobo-Jimenez Gibran J, Lara-Palazuelos Nathaniel, Zavala-Cerna Maria G

机构信息

Sports Medicine Division, Rehabilitem, Guadalajara 44100, Mexico.

Unidad Académica Ciencias de la Salud, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico.

出版信息

Reports (MDPI). 2024 Jul 30;7(3):62. doi: 10.3390/reports7030062.

DOI:10.3390/reports7030062
PMID:40729285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12225332/
Abstract

The treatment of osteochondritis dissecans of the knee has always been a challenge for orthopedic surgeons. We present a case report of a 38-year-old male with severe right knee pain after suffering from an indirect trauma and axial rotation of the knee, limiting knee functionality and impeding his ability to walk, with a diagnosis of osteochondritis dissecans in the trochlea of the knee, who underwent arthroscopic treatment with matrix-induced autologous chondrocyte implantation (MACI). After the surgery, a physical therapy protocol for MACI was implemented, and magnetic resonance images with cartilage mapping were used to evaluate the recovery of the lesion. A total recovery was observed and evaluated with the modified Cincinnati knee rating system (mCKRS). A discussion is provided with evidence and general recommendations for the use of MACI in the treatment of adult OCD of the knee as a possible alternative to conventional treatments. Our case shows a rapid improvement in pain and functionality 2 months after surgery that progressed to full recovery within 6 months.

摘要

膝关节剥脱性骨软骨炎的治疗一直是骨科医生面临的挑战。我们报告一例38岁男性病例,该患者在膝关节受到间接创伤和轴向旋转后出现严重右膝疼痛,膝关节功能受限,行走能力受阻,诊断为膝关节滑车剥脱性骨软骨炎,接受了基质诱导自体软骨细胞植入术(MACI)的关节镜治疗。术后,实施了MACI物理治疗方案,并使用带有软骨成像的磁共振图像评估病变的恢复情况。采用改良辛辛那提膝关节评分系统(mCKRS)观察并评估了完全恢复情况。本文提供了相关证据及关于MACI用于治疗成人膝关节骨软骨损伤作为传统治疗可能替代方法的一般性建议的讨论。我们的病例显示,术后2个月疼痛和功能迅速改善,并在6个月内完全恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/129c902292ef/reports-07-00062-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/5d82ba7e65ad/reports-07-00062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/b5c2f068b751/reports-07-00062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/41a33f402a28/reports-07-00062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/ad796faad044/reports-07-00062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/fdcac4efaa1d/reports-07-00062-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/b44898f6bab4/reports-07-00062-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/129c902292ef/reports-07-00062-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/5d82ba7e65ad/reports-07-00062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/b5c2f068b751/reports-07-00062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/41a33f402a28/reports-07-00062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/ad796faad044/reports-07-00062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/fdcac4efaa1d/reports-07-00062-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/b44898f6bab4/reports-07-00062-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e2c/12225332/129c902292ef/reports-07-00062-g007.jpg

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本文引用的文献

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Orthop Surg. 2023 Feb;15(2):549-562. doi: 10.1111/os.13662. Epub 2023 Jan 17.
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A systematic review of cartilage procedures for unstable osteochondritis dissecans.不稳定剥脱性骨软骨炎软骨手术治疗的系统评价
Phys Sportsmed. 2023 Dec;51(6):497-505. doi: 10.1080/00913847.2022.2082262. Epub 2022 May 31.
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Osteochondritis Dissecans: Current Understanding of Epidemiology, Etiology, Management, and Outcomes.
剥脱性骨软骨炎:流行病学、病因、治疗和结局的最新认识。
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Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach.基于细胞的治疗选择通过全关节方法在膝关节苛刻条件下促进软骨、韧带和半月板的再生。
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