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游走脾合并血小板减少症、急性阑尾炎和脓毒症:一例报告及文献综述

Wandering Spleen Complicated by Thrombocytopenia, Acute Appendicitis, and Sepsis: A Case Report and Literature Review.

作者信息

Inggriani Sri, Sulay Callistus Bruce Henfry, Octavius Gilbert Sterling

机构信息

Abdominal Radiology, Department of Radiology, Faculty of Universitas Pelita Harapan, Tangerang 12930, Indonesia.

Medistra Hospital, Jakarta 12950, Indonesia.

出版信息

Reports (MDPI). 2024 Sep 2;7(3):73. doi: 10.3390/reports7030073.

DOI:10.3390/reports7030073
PMID:40729296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12225254/
Abstract

Wandering spleen (WS) is a rare condition often linked with torsion or infarction, but its association with Bochdalek hernia, acute appendicitis, and thrombocytopenia is exceptionally rare. We present a case of a nine-year-old girl who was admitted with acute abdominal pain, later diagnosed with WS, Bochdalek hernia, and acute appendicitis. A literature search was performed on PubMed and Google Scholar on 30 May 2024 with keywords including "Wandering spleen" and ("Bochdalek Hernia" OR "Sepsis" OR "Acute Appendicitis" OR "Thrombocytopenia"). The management was complicated by severe thrombocytopenia and post-operative sepsis, with as the causative agent. Imaging revealed an abnormally located spleen and significant splenic enlargement over time. The patient's condition was managed non-operatively concerning the WS, avoiding splenectomy due to the risks of post-splenectomy sepsis. Instead, laparotomy was performed to address the appendicitis and diaphragmatic hernia. The patient experienced post-operative complications, including a seizure and persistent fever, which resolved with appropriate antibiotic therapy. This case underscores the complexity of managing WS with concurrent severe conditions, highlighting the importance of individualised treatment strategies. It also emphasises the need for further studies to explore optimal treatment modalities for such rare and complex presentations. This case serves as an educational example in clinical settings, demonstrating the challenges and considerations when treating multiple rare pathologies simultaneously.

摘要

游走脾(WS)是一种罕见病症,常与扭转或梗死相关,但它与博赫dalek疝、急性阑尾炎和血小板减少症的关联极为罕见。我们报告一例9岁女孩,因急性腹痛入院,后来被诊断为游走脾、博赫dalek疝和急性阑尾炎。于2024年5月30日在PubMed和谷歌学术上进行了文献检索,关键词包括“游走脾”以及(“博赫dalek疝”或“脓毒症”或“急性阑尾炎”或“血小板减少症”)。治疗因严重血小板减少症和术后脓毒症而变得复杂, 为病原体。影像学检查显示脾脏位置异常且随时间显著肿大。鉴于游走脾,患者的病情采用非手术治疗,由于脾切除术后脓毒症的风险而避免进行脾切除术。取而代之的是,进行剖腹手术以处理阑尾炎和膈疝。患者术后出现并发症,包括癫痫发作和持续发热,经适当的抗生素治疗后得到缓解。该病例强调了在伴有并发严重病症的情况下管理游走脾的复杂性,突出了个体化治疗策略的重要性。它还强调需要进一步研究以探索针对此类罕见且复杂病症的最佳治疗方式。该病例在临床环境中作为一个教育实例,展示了同时治疗多种罕见病症时的挑战和注意事项。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60f/12225254/68689b840815/reports-07-00073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60f/12225254/0dd672a2c16f/reports-07-00073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60f/12225254/68689b840815/reports-07-00073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60f/12225254/0dd672a2c16f/reports-07-00073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60f/12225254/68689b840815/reports-07-00073-g002.jpg

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本文引用的文献

1
Wandering Spleen with Splenic Torsion: Unusual Cause of Acute Abdomen.游走脾伴脾扭转:急性腹痛的罕见病因。
Int Med Case Rep J. 2022 Nov 4;15:625-630. doi: 10.2147/IMCRJ.S388271. eCollection 2022.
2
Laparoscopic Splenectomy of a Wandering Pelvic Splenomegaly in a Young Woman Treated in Childhood with Surgery for Diaphragmatic Hernia and Adhesiolysis for Intestinal Obstruction.腹腔镜下脾切除术治疗游走性盆腔脾肿大:该患者为年轻女性,儿时因膈疝接受过手术治疗,成年后因粘连性肠梗阻接受过粘连松解术。
Am J Case Rep. 2022 Oct 3;23:e936964. doi: 10.12659/AJCR.936964.
3
A case report of wandering spleen with pedicle torsion and splenic infarction being misdiagnosed as organ inversion complicated with acute appendicitis.
游走脾伴蒂扭转及脾梗死误诊为脏器反位合并急性阑尾炎1例报告
Front Surg. 2022 Sep 6;9:916426. doi: 10.3389/fsurg.2022.916426. eCollection 2022.
4
Volvulus of the stomach and wandering spleen after repair of congenital diaphragmatic hernia: unexpected manifestations in a neonate.先天性膈疝修补术后胃扭转和游走脾:新生儿中的意外表现
Surg Case Rep. 2022 Sep 23;8(1):178. doi: 10.1186/s40792-022-01537-z.
5
Treatment of a congenital diaphragmatic hernia with associated wandering spleen: Case report of a 17-year-old girl.先天性膈疝合并游走脾的治疗:一名17岁女孩的病例报告。
Int J Surg Case Rep. 2020;77:32-35. doi: 10.1016/j.ijscr.2020.10.049. Epub 2020 Oct 22.
6
Wandering Spleen Volvulus: A Case Report and Literature Review of This Diagnostic Challenge.游走脾扭转:一例报告及对此诊断难题的文献综述
Am J Case Rep. 2020 Sep 1;21:e925301. doi: 10.12659/AJCR.925301.
7
capsule polysaccharide as a target for therapeutics and vaccines.作为治疗药物和疫苗靶点的荚膜多糖
Comput Struct Biotechnol J. 2019 Oct 25;17:1360-1366. doi: 10.1016/j.csbj.2019.09.011. eCollection 2019.
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Wandering spleen with chronic torsion in a patient with thalassaemia.一名地中海贫血患者出现游走脾伴慢性扭转。
Singapore Med J. 2014 Dec;55(12):e198-200. doi: 10.11622/smedj.2014185.
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A torted wandering spleen: a case report.一例扭转游走脾:病例报告
J Med Case Rep. 2014 May 1;8:133. doi: 10.1186/1752-1947-8-133.
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Splenic anomalies of shape, size, and location: pictorial essay.脾脏在形状、大小和位置上的异常:图文综述
ScientificWorldJournal. 2013 Apr 21;2013:321810. doi: 10.1155/2013/321810. Print 2013.